Reumafen Tablet 200 mg contains Ibuprofen, a widely used non-steroidal anti-inflammatory drug (NSAID) with potent analgesic, anti-inflammatory, and antipyretic properties. It is primarily indicated for the relief of mild to moderate pain, inflammation, and fever associated with a variety of conditions such as musculoskeletal disorders, arthritis, dental pain, and post-operative discomfort. By inhibiting the production of prostaglandins, Reumafen 200 mg effectively reduces pain, swelling, and inflammation, offering rapid and reliable symptomatic relief.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Reumafen 200 mg is indicated for:

• Pain relief in conditions such as headache, dental pain, menstrual cramps, and musculoskeletal pain.

• Anti-inflammatory treatment for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and other inflammatory joint disorders.

• Fever reduction in acute febrile conditions.

• Post-operative or injury-related pain and swelling.

Therapeutic Class

Non-steroidal anti-inflammatory drug (NSAID) – Analgesic, Anti-inflammatory, Antipyretic

Pharmacology

Ibuprofen, the active ingredient in Reumafen 200 mg, is a propionic acid derivative that inhibits cyclooxygenase (COX-1 and COX-2) enzymes. These enzymes are responsible for the conversion of arachidonic acid into prostaglandins, which are mediators of pain, inflammation, and fever. By reducing prostaglandin synthesis, Ibuprofen decreases:

• Inflammation: Reduces swelling, redness, and pain in inflamed tissues.

• Pain sensation: Provides relief from acute and chronic pain.

• Fever: Lowers elevated body temperature in febrile states.

The drug is rapidly absorbed from the gastrointestinal tract and has a plasma half-life of approximately 2 hours, allowing for effective pain control with multiple daily doses.

Dosage and Administration

• Adults and adolescents (12 years and older): 200–400 mg every 4–6 hours as needed. Maximum daily dose should not exceed 1200 mg for over-the-counter use, or 2400 mg under medical supervision.

• Children under 12 years: Use pediatric formulations; dosing based on body weight as prescribed by a physician.

• Take with food or milk to reduce the risk of gastrointestinal irritation.

• Swallow tablets whole with a sufficient amount of water.

Drug Interactions

• Anticoagulants (e.g., warfarin): May increase bleeding risk.

• Other NSAIDs or corticosteroids: Increased risk of gastrointestinal ulceration or bleeding.

• Antihypertensive drugs: NSAIDs may reduce efficacy of ACE inhibitors, ARBs, or diuretics.

• Lithium or methotrexate: Risk of increased plasma levels and toxicity.

Contraindications

• Hypersensitivity to Ibuprofen or other NSAIDs.

• History of NSAID-induced asthma, urticaria, or allergic reactions.

• Active gastrointestinal bleeding, peptic ulcer, or severe liver/kidney impairment.

• Third trimester of pregnancy.

Side Effects

Common side effects include:

• Gastrointestinal discomfort: nausea, vomiting, dyspepsia, abdominal pain

• Headache, dizziness

• Rash or mild allergic reactions

• Rare but serious effects: gastrointestinal bleeding, renal impairment, cardiovascular events

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Gastrointestinal risk: Use the lowest effective dose for the shortest duration to minimize ulceration or bleeding.

• Renal and hepatic monitoring: Recommended in patients with kidney or liver disease.

• Cardiovascular caution: Long-term use may increase risk of heart attack or stroke.

• Pregnancy & Lactation: Avoid in the third trimester; use during pregnancy only if benefits outweigh risks. Caution is advised during breastfeeding.

Storage Conditions

Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.

Mode of Action

Reumafen 200 mg works by inhibiting cyclooxygenase enzymes, thereby reducing prostaglandin synthesis. This leads to decreased inflammation, pain, and fever, while providing relief in a variety of musculoskeletal and inflammatory conditions. Its analgesic and anti-inflammatory properties make it suitable for both acute and chronic management of pain-related disorders.