Edemide Tablet 40 mg+50 mg is a combination diuretic therapy containing Furosemide 40 mg and Spironolactone 50 mg. This formulation is designed to treat edema associated with heart failure, liver cirrhosis, and kidney disorders, while helping to maintain electrolyte balance.

Furosemide is a loop diuretic that promotes the excretion of sodium, chloride, and water, resulting in rapid reduction of fluid accumulation. Spironolactone is a potassium-sparing diuretic and aldosterone antagonist, which helps prevent potassium loss and reduces fluid retention by promoting sodium excretion without significant potassium depletion. Together, they provide synergistic diuretic effects, effectively managing edema while minimizing the risk of hypokalemia.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Furosemide: 40 mg

• Spironolactone: 50 mg

Indications

Edemide Tablet 40 mg+50 mg is indicated for:

• Edema associated with congestive heart failure

• Liver cirrhosis with ascites or peripheral edema

• Nephrotic syndrome or chronic kidney disease causing fluid retention

• Hypertension with fluid overload

• As an adjunct therapy in conditions requiring diuretic treatment while preserving potassium

Mechanism of Action

Edemide Tablet combines two complementary diuretics to achieve effective fluid removal:

1. Furosemide (Loop Diuretic):

   • Inhibits the Na⁺-K⁺-2Cl⁻ symporter in the loop of Henle.

   • Increases excretion of sodium, chloride, and water, leading to rapid diuresis.

   • Reduces edema, blood pressure, and fluid overload.

2. Spironolactone (Potassium-Sparing Diuretic):

   • Acts as an aldosterone antagonist in the distal renal tubules.

   • Promotes sodium and water excretion while retaining potassium and hydrogen ions.

   • Helps prevent hypokalemia caused by loop diuretics and supports electrolyte balance.

Together, this combination provides balanced and effective diuretic therapy, reducing edema and improving symptoms of fluid overload.

Dosage and Administration

• Route: Oral

• Dosage: As prescribed by a registered physician

The usual adult dose is one tablet daily or as directed, depending on the severity of edema and kidney function. Tablets should be taken with water, preferably in the morning to prevent nighttime urination. Patients should maintain adequate hydration and monitor urine output, weight, and blood pressure during therapy. Regular laboratory tests for electrolytes, kidney function, and liver function are recommended.

Benefits of Edemide Tablet 40 mg+50 mg

• Effective management of edema in heart, liver, and kidney disorders

• Potassium-sparing effect reduces risk of hypokalemia

• Balanced diuretic therapy for long-term use

• Helps control blood pressure in patients with fluid overload

• Convenient combination tablet improves adherence

• Well-tolerated under medical supervision

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use only under medical supervision

• Contraindicated in patients with anuria, severe kidney failure, hyperkalemia, or hypersensitivity to Furosemide or Spironolactone

• Caution in patients with liver or kidney impairment, diabetes, or electrolyte imbalances

• Monitor for side effects such as dizziness, dehydration, low blood pressure, or electrolyte disturbances

• Avoid excessive use of potassium supplements unless prescribed

• Seek immediate medical attention for muscle weakness, irregular heartbeat, or severe dehydration

Storage Conditions

• Store below 30°C in a dry place

• Protect from light and moisture

• Keep out of reach of children

Pharmaceutical Category

Diuretic / Combination Therapy / Antiedematous Agent.