Palnox Injection 0.25 mg/5 ml contains Palonosetron, a selective 5-HT3 receptor antagonist used primarily to prevent nausea and vomiting associated with chemotherapy, radiotherapy, or surgery. Palonosetron works by blocking serotonin (5-HT3) receptors in the central nervous system and gastrointestinal tract, which play a key role in triggering the vomiting reflex.

The injectable formulation ensures rapid systemic absorption, providing fast and reliable antiemetic protection. Palnox is particularly effective in preventing both acute (within 24 hours) and delayed (24–120 hours) chemotherapy-induced nausea and vomiting (CINV). Its longer half-life compared to other 5-HT3 antagonists allows for single-dose administration in many cases, enhancing convenience for both patients and healthcare providers.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Palnox Injection 0.25 mg/5 ml is indicated for:

• Prevention of chemotherapy-induced nausea and vomiting (CINV): Especially in moderately to highly emetogenic chemotherapy regimens.

• Prevention of postoperative nausea and vomiting (PONV): Reducing the incidence of nausea and vomiting after surgical procedures.

• Radiotherapy-induced nausea and vomiting: For patients undergoing radiotherapy with a high risk of emesis.

It is intended for use in hospital or clinic settings under the supervision of trained healthcare professionals.

Key Benefits

• Potent antiemetic: Effectively blocks serotonin-mediated nausea and vomiting.

• Rapid onset of action: Provides quick relief for acute emetic episodes.

• Long-acting effect: Extended half-life ensures protection against delayed nausea and vomiting, reducing the need for repeated dosing.

• Single-dose convenience: Simplifies treatment protocols for chemotherapy and surgery.

• Well tolerated: Minimal sedative or cardiovascular side effects compared to older antiemetics.

Palnox Injection offers a reliable solution for patients at high risk of nausea and vomiting, improving comfort and adherence to chemotherapy or surgical recovery protocols.

Dosage and Administration

• Adults: Typically, 0.25 mg administered as a slow IV injection over 30 seconds, given approximately 30 minutes before chemotherapy or at the start of surgery.

• For highly emetogenic chemotherapy, Palnox may be combined with dexamethasone or other antiemetics for enhanced efficacy.

• No dose adjustment is usually required for mild to moderate renal or hepatic impairment, but caution is advised in severe cases.

• Ensure the injection is administered slowly and aseptically to minimize local irritation or systemic side effects.

Precautions

• Avoid use in patients with known hypersensitivity to Palonosetron or other 5-HT3 antagonists.

• Use with caution in patients with cardiac arrhythmias, prolonged QT interval, or electrolyte imbalances, as rare cardiac effects may occur.

• Inform the physician of other medications, particularly those that may prolong the QT interval.

• Monitor patients for signs of severe allergic reaction, serotonin syndrome, or unusual cardiac symptoms during therapy.

• Pregnant or breastfeeding women should use only under strict medical supervision.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Palnox Injection is generally well tolerated. Common side effects may include:

• Headache or dizziness

• Constipation

• Mild fatigue or weakness

• Injection site reactions such as redness or discomfort

Rare but serious side effects may include:

• Severe hypersensitivity reactions (rash, swelling, anaphylaxis)

• Cardiac arrhythmias or prolonged QT interval

• Severe constipation or intestinal obstruction

Seek immediate medical attention if serious side effects occur.

Storage Instructions

• Store at 2–8°C in a refrigerator; do not freeze.

• Keep the vial protected from light and in its original packaging until use.

• Use immediately after opening and ensure aseptic handling.

• Keep out of reach of children.

Palnox Injection 0.25 mg/5 ml (Palonosetron) is a safe, fast-acting, and effective antiemetic for preventing nausea and vomiting associated with chemotherapy, radiotherapy, and surgery, improving patient comfort and treatment compliance.