Doltro Injection 30 mg/ml contains Ketorolac Tromethamine 30 mg per ml, a potent non-steroidal anti-inflammatory drug (NSAID) used for the short-term management of moderate to severe pain. Administered via intravenous (IV) or intramuscular (IM) routes, this formulation provides rapid and effective analgesia, making it ideal for conditions such as postoperative pain, musculoskeletal injuries, renal colic, or acute inflammatory pain.

Ketorolac, the active ingredient, works by inhibiting cyclooxygenase (COX) enzymes, which reduces the production of prostaglandins, chemical mediators responsible for pain, inflammation, and fever. Doltro Injection 30 mg/ml provides fast-acting relief, especially in patients who cannot take oral analgesics or require rapid pain management in clinical settings.

This formulation is commonly used in hospitals, emergency departments, and post-surgical units, helping patients achieve effective pain control while reducing reliance on opioids. Its short-term use ensures potent pain relief with a reduced risk of long-term adverse effects.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Doltro Injection 30 mg/ml is indicated for:

• Postoperative pain, including orthopedic, dental, or abdominal surgeries

• Acute musculoskeletal pain, such as sprains, strains, or back pain

• Renal colic pain management

• Short-term treatment of moderate to severe acute pain where oral therapy is unsuitable

Key Benefits

• Provides rapid onset of analgesia for immediate relief

• Reduces pain, inflammation, and swelling associated with acute conditions

• Non-opioid therapy, reducing the risk of dependence

• Suitable for patients unable to take oral NSAIDs

• Effective short-term pain control in hospital or emergency settings

Mechanism of Action

Ketorolac Tromethamine is a non-selective COX-1 and COX-2 inhibitor. COX enzymes are responsible for the synthesis of prostaglandins, which mediate pain, inflammation, and fever.

• Analgesic effect: Reduces pain by blocking prostaglandin-mediated stimulation of nerve endings.

• Anti-inflammatory effect: Decreases inflammation by limiting prostaglandin-induced vasodilation and fluid accumulation.

• Antipyretic effect: Helps lower fever by modulating hypothalamic prostaglandin activity.

By targeting these pathways, Doltro Injection provides fast and effective relief from acute pain and inflammation.

Dosage and Administration

• Adults: 30 mg per ml via IM or IV injection, depending on clinical need.

• Maximum recommended dose: 120 mg per day, administered in divided doses every 6 hours.

• IV administration: Inject slowly over 15–30 seconds to minimize local irritation.

• IM administration: Inject into a large muscle mass (gluteal or thigh).

• Therapy should not exceed 5 days due to potential adverse effects with prolonged use.

Precautions

• Contraindicated in patients with active gastrointestinal bleeding, peptic ulcers, renal failure, or hypersensitivity to NSAIDs.

• Avoid concurrent use with other NSAIDs, anticoagulants, or corticosteroids unless prescribed.

• Use cautiously in elderly patients, those with cardiovascular disease, or impaired liver/kidney function.

• Not recommended during late pregnancy due to fetal risk.

• Monitor for gastrointestinal bleeding, renal dysfunction, and allergic reactions during therapy.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Doltro Injection 30 mg/ml is generally well tolerated. Side effects may include:

• Injection site irritation or pain

• Nausea, heartburn, or gastrointestinal discomfort

• Headache or dizziness

• Rarely, gastrointestinal bleeding, renal dysfunction, or allergic reactions

Most side effects are mild and transient, resolving with dose adjustment or discontinuation.

Storage

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children. Use single-use vials only once and discard any remaining solution.