Divastin-E Tablet 10 mg+10 mg is a combination lipid-lowering medication containing Atorvastatin 10 mg and Ezetimibe 10 mg, designed for the management of high cholesterol and mixed dyslipidemia. This dual-action formulation targets cholesterol through two complementary mechanisms: Atorvastatin reduces cholesterol production in the liver, while Ezetimibe inhibits the absorption of cholesterol from the intestine.

Atorvastatin, a statin, works by inhibiting HMG-CoA reductase, the enzyme responsible for cholesterol synthesis. This results in a significant reduction in low-density lipoprotein (LDL) cholesterol, a modest increase in high-density lipoprotein (HDL) cholesterol, and a decrease in triglycerides.

Ezetimibe acts at the brush border of the small intestine to selectively inhibit the absorption of dietary and biliary cholesterol. This complementary action enhances the overall cholesterol-lowering effect of the combination therapy, making Divastin-E particularly effective in patients who do not achieve adequate lipid control with statin monotherapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Divastin-E Tablet 10 mg+10 mg is indicated for:

• Primary hypercholesterolemia: For adults with elevated total cholesterol, LDL cholesterol, and triglycerides

• Mixed dyslipidemia: When both LDL and triglycerides are elevated

• Patients inadequately controlled with statin monotherapy: To achieve target LDL cholesterol levels

• Prevention of cardiovascular events: In adults at high risk of heart attack, stroke, or coronary artery disease

• Adjunct therapy with lifestyle interventions, including a low-fat diet, regular exercise, and weight management

This combination is suitable for patients requiring intensive lipid-lowering therapy while minimizing the dose of statin needed, which may help reduce statin-related side effects.

Dosage and Administration

• Adults: Usually, one tablet orally once daily, with or without food, as prescribed by a physician.

• Administer at the same time each day to maintain consistent blood levels.

• Patients should continue following a heart-healthy diet and lifestyle to maximize therapeutic benefits.

Dosage adjustments may be required in patients with liver impairment or other comorbidities, under the supervision of a healthcare professional.

Precautions

• Contraindicated in patients with active liver disease, unexplained persistent elevations in liver enzymes, or hypersensitivity to Atorvastatin, Ezetimibe, or any component of the tablet.

• Use with caution in patients with renal impairment, liver disease, or a history of muscle disorders.

• May interact with other medications such as certain antifungals, antibiotics, or immunosuppressants; consult a physician before combining therapies.

• Pregnant or breastfeeding women should avoid use, as Atorvastatin may harm the fetus or infant.

• Regular monitoring of liver function, kidney function, and lipid profile is recommended during treatment.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Divastin-E Tablet is generally well tolerated. Common side effects may include:

• Gastrointestinal discomfort such as nausea, constipation, or abdominal pain

• Headache or mild fatigue

• Muscle pain, cramps, or weakness

Rare but serious side effects may include:

• Myopathy or rhabdomyolysis (severe muscle breakdown)

• Liver enzyme abnormalities or liver dysfunction

• Allergic reactions including rash, itching, or swelling

Patients should immediately report unexplained muscle pain, dark urine, jaundice, or persistent fatigue to a healthcare professional.

Storage

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.

Divastin-E Tablet 10 mg+10 mg provides effective dual-action cholesterol control, combining the liver-targeted effect of Atorvastatin with the intestinal absorption inhibition of Ezetimibe, helping patients achieve optimal lipid levels and reduce cardiovascular risk under medical supervision.