Diparin Injection 25,000 IU/5 ml contains Heparin Sodium, a potent anticoagulant used to prevent and treat blood clots. Heparin is a naturally occurring glycosaminoglycan that enhances the activity of antithrombin III, an enzyme that inhibits clotting factors IIa (thrombin) and Xa. By preventing the formation of fibrin, Heparin effectively reduces the risk of thrombosis in high-risk patients and helps manage existing clotting disorders.

Diparin is commonly used in hospital and clinical settings for its rapid onset of action and short half-life, which allows precise control of anticoagulation therapy. It is administered subcutaneously or intravenously under strict medical supervision. This formulation, with 25,000 IU in 5 ml, provides a concentrated option for patients requiring high-dose anticoagulation therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Diparin Injection is indicated for:

• Prevention of deep vein thrombosis (DVT) in immobilized or post-surgical patients

• Treatment of acute venous thromboembolism (VTE) including DVT and pulmonary embolism

• Prevention of clot formation in extracorporeal circulation during dialysis or cardiac surgery

• Management of unstable angina or myocardial infarction in specific clinical protocols

• Prophylaxis in patients at high risk of thrombosis due to medical conditions or surgery

Heparin is particularly important in patients who cannot take oral anticoagulants or require immediate anticoagulant effects.

Dosage and Administration

The dosage of Diparin Injection varies depending on clinical condition, patient weight, and monitoring of coagulation parameters:

• Prophylactic dose: Typically 5,000 IU subcutaneously every 8–12 hours in adults, as prescribed.

• Therapeutic dose: Administered intravenously or subcutaneously with dose adjustments based on activated partial thromboplastin time (aPTT) or anti-Xa activity.

• Pediatric and elderly dosing must be individualized by a physician.

Administration Notes:

• IV administration should be done using a controlled infusion device.

• Subcutaneous injections should be given in the abdominal wall, avoiding areas with bruising or scars.

• Regular monitoring of coagulation parameters is essential to prevent under- or over-anticoagulation.

Precautions

• Contraindicated in patients with active bleeding, severe thrombocytopenia, or hypersensitivity to Heparin.

• Use with caution in patients with liver disease, kidney disease, or history of heparin-induced thrombocytopenia (HIT).

• Careful monitoring is required when used with other anticoagulants or antiplatelet medications.

• Avoid invasive procedures or surgery during therapy unless necessary, and take precautions to reduce bleeding risk.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Diparin Injection is generally safe under medical supervision. Side effects may include:

• Mild bleeding at injection site

• Bruising or hematoma

• Thrombocytopenia (rare but serious)

• Allergic reactions including rash, fever, or anaphylaxis (rare)

• Elevated liver enzymes (rare)

Immediate medical attention is required if severe bleeding, unusual bruising, or symptoms of thrombocytopenia occur.

Storage

Store below 25°C in a cool, dry place, protected from light. Keep out of reach of children. Do not use the solution if it is discolored or contains particles.

Diparin Injection 25,000 IU/5 ml provides rapid and effective anticoagulation for prevention and management of thromboembolic conditions under strict medical supervision, ensuring patient safety and optimal therapeutic outcomes.