Demoxiclave Tablet 875 mg+125 mg is a combination antibiotic containing Amoxicillin (875 mg) and Clavulanic Acid (125 mg), designed to treat a wide range of bacterial infections. Amoxicillin is a broad-spectrum penicillin antibiotic effective against many Gram-positive and Gram-negative bacteria, while Clavulanic Acid is a beta-lactamase inhibitor that prevents the degradation of Amoxicillin by bacterial enzymes, enhancing its efficacy.

Demoxiclave Tablet is particularly effective in treating infections where bacteria produce beta-lactamase, which can make standard penicillin therapy ineffective. This combination ensures rapid bacterial eradication, reduces infection severity, and helps prevent complications.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Mechanism of Action

• Amoxicillin: Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death of susceptible bacteria.

• Clavulanic Acid: Protects Amoxicillin from enzymatic degradation by beta-lactamase-producing bacteria, restoring its antibacterial activity.

• The combination ensures a bactericidal effect against resistant strains of bacteria, making it suitable for complex or recurrent infections.

Together, these agents provide a potent antibacterial action, effectively controlling infections and reducing bacterial resistance.

Indications

Demoxiclave Tablet 875 mg+125 mg is indicated for:

• Respiratory tract infections: bronchitis, pneumonia, sinusitis, and tonsillitis

• Ear, nose, and throat infections: otitis media, pharyngitis, and tonsillitis

• Skin and soft tissue infections: cellulitis, abscesses, and wound infections

• Urinary tract infections (UTIs): cystitis and pyelonephritis

• Bone and joint infections: caused by susceptible bacterial strains

• Dental infections: periodontitis and odontogenic abscesses

• Other infections caused by beta-lactamase-producing bacteria

It is suitable for both adults and children (with adjusted dosing) under medical supervision.

Dosage and Administration

• Adults: Usually one tablet twice daily, or as prescribed by a physician.

• Children: Dose is calculated based on body weight. Pediatric formulations are recommended for accurate dosing.

• Swallow the tablet whole with water, preferably after meals to reduce gastrointestinal discomfort.

• Complete the full course of therapy, even if symptoms improve, to prevent recurrence and bacterial resistance.

• Dosage adjustments may be required in patients with renal impairment.

Precautions and Safety Information

• Use with caution in patients with penicillin allergy, liver or kidney disorders, or history of gastrointestinal disease.

• May interact with other medications, including anticoagulants, oral contraceptives, and other antibiotics.

• Rarely, Demoxiclave may cause Clostridium difficile-associated diarrhea. Seek medical attention if severe diarrhea occurs.

• Not recommended for viral infections such as cold or flu, as antibiotics are ineffective against viruses.

• Report any signs of allergic reaction, such as rash, itching, swelling, or breathing difficulty.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects include:

• Gastrointestinal upset – nausea, vomiting, diarrhea, abdominal discomfort

• Mild headache or dizziness

• Skin rash or itching

• Rarely, liver enzyme abnormalities or severe allergic reactions

Most side effects are mild and resolve with continued treatment or dose adjustment.

Storage Instructions

Store Demoxiclave Tablet 875 mg+125 mg in a cool, dry place, away from light and moisture. Keep out of reach of children.

Demoxiclave Tablet 875 mg+125 mg provides effective, broad-spectrum antibacterial therapy, helping treat infections caused by resistant bacteria while reducing the risk of complications and supporting recovery.