Synamet Plus Tablet 100 mg+25 mg+200 mg is a combination medicine used for the treatment of Parkinson’s disease, especially in patients with advanced symptoms or motor fluctuations. It contains Levodopa, Carbidopa, and Entacapone, which work together to improve movement control, reduce tremors, and provide more stable symptom relief throughout the day.

This triple therapy helps maintain consistent dopamine levels in the brain and reduces “wearing-off” effects commonly seen with Levodopa therapy alone.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Levodopa 100 mg
• Carbidopa 25 mg
• Entacapone 200 mg
• Dosage Form: Oral Tablet

Indications

Synamet Plus Tablet is indicated for:

• Parkinson’s disease (advanced stages)
• Motor fluctuations (“on-off” episodes)
• Wearing-off effect of Levodopa therapy
• Tremors, rigidity, and bradykinesia
• Dopamine deficiency-related movement disorders

How Synamet Plus Tablet Works

This combination works through three complementary mechanisms:

• Levodopa: Converts into dopamine in the brain, improving movement and coordination.
• Carbidopa: Prevents premature breakdown of Levodopa in the body, increasing its availability in the brain and reducing side effects like nausea.
• Entacapone: Inhibits the COMT enzyme, prolonging the effect of Levodopa and helping maintain steady dopamine levels.

Together, they provide smoother and longer-lasting control of Parkinson’s symptoms.

Dosage and Administration

• Take exactly as prescribed by a physician.
• Usually taken with or after Levodopa doses as part of a scheduled regimen.
• Can be taken with or without food, but consistent timing is important.
• Do not stop the medicine suddenly without medical advice.

Dosage is adjusted based on patient response and disease severity.

Benefits of Synamet Plus Tablet 100 mg + 25 mg + 200 mg

• Improves movement control and coordination
• Reduces tremors, stiffness, and slowness
• Helps control “wearing-off” and motor fluctuations
• Provides longer-lasting effect of Levodopa
• Enhances daily functional ability in Parkinson’s patients

Possible Side Effects

Some patients may experience:

• Nausea or vomiting
• Dizziness or low blood pressure
• Involuntary movements (dyskinesia)
• Diarrhea (due to Entacapone)
• Sleep disturbances
• Urine discoloration (orange/brown, harmless effect of Entacapone)

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use only under neurological supervision
• Do not discontinue abruptly
• May cause drowsiness—avoid driving if affected
• Use cautiously in liver, kidney, or heart disease
• May interact with antidepressants and other CNS drugs
• Regular monitoring is recommended during long-term therapy

Storage Instructions

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.