Dactus Tablet 1 mg contains Glimepiride, an oral antidiabetic medication belonging to the sulfonylurea class. It is primarily used for the management of type 2 diabetes mellitus in adults and children over the age of 18. Glimepiride helps control blood glucose levels by stimulating insulin secretion from pancreatic beta cells and improving peripheral insulin sensitivity. Its once-daily dosing, effectiveness, and relatively low risk of weight gain make Dactus Tablet a widely prescribed choice for maintaining optimal glycemic control.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Glimepiride 1 mg

• Dosage Form: Oral tablet

• Route of Administration: Oral

Mechanism of Action

Glimepiride lowers blood glucose through two primary mechanisms:

1. Stimulation of insulin release: Glimepiride binds to sulfonylurea receptors on pancreatic beta cells, leading to the closure of ATP-sensitive potassium channels, depolarization of the cell membrane, and increased insulin secretion.

2. Improved peripheral insulin sensitivity: It enhances the ability of insulin to promote glucose uptake in skeletal muscles and suppress hepatic glucose production, contributing to overall glycemic control.

By combining these effects, Dactus Tablet helps reduce both fasting and postprandial blood glucose levels.

Indications

Dactus Tablet 1 mg is indicated for:

• Type 2 diabetes mellitus in adults and adolescents over 18 years of age

• Patients with inadequate glycemic control despite diet, exercise, and lifestyle modifications

• Use as monotherapy or in combination with other oral antidiabetic agents or insulin when appropriate

• Management of hyperglycemia to prevent long-term diabetic complications, such as neuropathy, nephropathy, and cardiovascular issues

Dosage and Administration

• The usual starting dose is 1 mg once daily, taken with breakfast or the first main meal to reduce the risk of hypoglycemia.

• The dose may be adjusted based on blood glucose levels and patient response, typically up to a maximum of 8 mg per day.

• Swallow the tablet whole with water. Do not crush or chew.

• Maintain consistent diet, exercise, and monitoring to optimize therapy.

• Regular blood glucose monitoring is essential to avoid hypoglycemia or hyperglycemia.

Contraindications

Dactus Tablet is contraindicated in:

• Patients with hypersensitivity to Glimepiride or other sulfonylureas

• Type 1 diabetes mellitus

• Diabetic ketoacidosis

• Severe renal or hepatic impairment

• Pregnancy and breastfeeding unless specifically directed by a physician

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Risk of hypoglycemia, particularly in elderly patients, those with irregular meals, or concurrent use of other antidiabetic medications

• Use caution in patients with impaired renal or hepatic function

• Monitor blood glucose regularly, especially during changes in diet, exercise, or concurrent medications

• Adjust dose in elderly patients to minimize hypoglycemic episodes

Possible Side Effects

Dactus Tablet is generally well tolerated. Common side effects may include:

• Hypoglycemia (low blood sugar)

• Nausea, vomiting, or gastrointestinal discomfort

• Mild dizziness or headache

• Rare effects: allergic skin reactions, liver enzyme alterations, or hematological changes

Storage

Store below 30°C in a cool, dry place. Protect from moisture and light. Keep out of reach of children.

Conclusion

Dactus Tablet 1 mg provides effective blood glucose control in patients with type 2 diabetes mellitus. Its dual mechanism of stimulating insulin release and improving insulin sensitivity helps maintain stable blood glucose levels and reduce the risk of long-term diabetic complications. When combined with diet, exercise, and regular monitoring, Dactus Tablet is a reliable option for managing type 2 diabetes under medical supervision.