Bigmet XR Tablet 500 mg contains Metformin Hydrochloride in an extended-release (XR) formulation, designed for the management of type 2 diabetes mellitus. Metformin, a biguanide class drug, works by:

• Reducing glucose production in the liver (gluconeogenesis)

• Increasing insulin sensitivity in peripheral tissues

• Enhancing glucose uptake and utilization by muscles

The XR formulation ensures gradual release of metformin over an extended period, which helps maintain stable blood glucose levels throughout the day and reduces gastrointestinal side effects commonly associated with immediate-release formulations.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Bigmet XR Tablet 500 mg is indicated for:

• Management of type 2 diabetes mellitus, especially in patients who require stable, long-acting glucose control

• Patients with insulin resistance who need improved glycemic regulation

• Use as monotherapy or in combination with other antidiabetic agents (including sulfonylureas, SGLT2 inhibitors, or insulin)

• Prevention of type 2 diabetes in high-risk individuals as part of lifestyle interventions

Benefits of Bigmet XR Tablet

• Provides sustained blood glucose control throughout the day

• Reduces the risk of postprandial glucose spikes

• Minimizes gastrointestinal side effects like nausea, bloating, and diarrhea

• Helps manage insulin resistance and improve peripheral glucose utilization

• Supports long-term diabetes management and reduces complications

Dosage and Administration

Bigmet XR Tablet should be taken exactly as prescribed by a healthcare professional.

• Typical dose: 500 mg once daily, preferably with the evening meal

• Tablets should be swallowed whole; do not crush, chew, or break

• Dose may be gradually increased based on glycemic response and tolerability, usually up to 2000 mg per day as advised by the doctor

• Regular blood glucose monitoring is recommended to assess effectiveness

Precautions

Before taking Bigmet XR Tablet, inform your doctor if you:

• Have kidney or liver impairment, as metformin may accumulate and increase risk of lactic acidosis

• Have a history of lactic acidosis, heart failure, or metabolic acidosis

• Are pregnant, planning pregnancy, or breastfeeding

• Are undergoing radiological procedures using contrast media, which may require temporary discontinuation

Patients should report any unusual symptoms such as severe fatigue, rapid breathing, or muscle pain, which could indicate rare complications.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Bigmet XR Tablet 500 mg is generally well-tolerated. Common side effects include:

• Mild gastrointestinal issues (nausea, diarrhea, bloating)

• Loss of appetite or metallic taste

• Rare vitamin B12 deficiency with prolonged use

• Very rare but serious: lactic acidosis, which requires immediate medical attention

Storage Instructions

Store Bigmet XR Tablet 500 mg in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.