Mizolam Tablet 7.5 mg contains Midazolam, a short-acting benzodiazepine widely used for its sedative, anxiolytic, and muscle-relaxant properties. This formulation is indicated for the management of acute anxiety, insomnia, and procedural sedation, providing rapid relief and promoting calmness in patients requiring short-term intervention. Mizolam offers a reliable option for controlled sedation under clinical supervision or for short-term use in outpatient settings.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Benzodiazepine / Sedative-Hypnotic

Indications

Mizolam Tablet 7.5 mg is indicated for:

• Short-term relief of acute anxiety or agitation

• Insomnia associated with anxiety

• Procedural sedation for minor surgical or diagnostic interventions

• Muscle relaxation in patients with spasticity or tension

Pharmacology

Midazolam acts on the central nervous system by enhancing the activity of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter. By binding to benzodiazepine receptors, it increases the frequency of chloride channel opening in neurons, resulting in:

• Sedation and anxiolysis

• Muscle relaxation

• Anticonvulsant effects in certain conditions
  Its rapid onset and short duration make it suitable for controlled, short-term use, minimizing prolonged sedation.

Dosage and Administration

• Adults: 7.5 mg orally, 30–60 minutes before the required sedative effect

• Elderly or debilitated patients: Lower doses may be required due to increased sensitivity

• Children: Use only under strict medical supervision; dosage must be individualized

• Swallow the tablet whole with water; may be taken with or without food

• Short-term use is recommended; prolonged therapy increases the risk of tolerance, dependence, and withdrawal symptoms

Side Effects

Common side effects may include:

• Drowsiness or sedation

• Dizziness or lightheadedness

• Headache

• Mild nausea or gastrointestinal discomfort

Less common but serious side effects:

• Respiratory depression, especially at higher doses or with concomitant CNS depressants

• Paradoxical reactions such as agitation, aggression, or hallucinations

• Dependence, tolerance, and withdrawal symptoms after prolonged use

• Hypotension or cardiac arrhythmias in sensitive patients

Contraindications

• Hypersensitivity to Midazolam or other benzodiazepines

• Severe respiratory insufficiency

• Acute narrow-angle glaucoma

• Pregnancy and lactation unless prescribed under strict medical supervision

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions & Warnings

• Use caution in elderly, debilitated, or patients with impaired hepatic or renal function

• Avoid alcohol or other CNS depressants while taking Mizolam

• Not recommended for long-term use due to risk of dependence

• Monitor patients for signs of excessive sedation or respiratory depression

• Abrupt discontinuation after prolonged use may lead to withdrawal symptoms

Drug Interactions

• Concomitant use with alcohol, opioids, or other sedatives may potentiate CNS depression

• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) can increase Midazolam plasma levels

• CYP3A4 inducers (e.g., rifampin, carbamazepine) may reduce efficacy

Storage

• Store below 30°C in a dry place

• Protect from light and moisture

• Keep out of reach of children

Mode of Action

Midazolam enhances the inhibitory effects of GABA in the CNS by binding to benzodiazepine receptors, producing sedation, anxiolysis, and muscle relaxation. Its rapid onset and short duration make Mizolam 7.5 mg effective for acute management of anxiety, insomnia, or procedural sedation.