Acme's Mannitol Injection 20% is a sterile intravenous solution containing Mannitol 20% w/v, formulated for use as an osmotic diuretic. It is widely utilized in hospital and critical care settings to reduce increased intracranial and intraocular pressure and to promote diuresis in specific clinical conditions. The injection is prepared under strict quality standards to ensure safety, purity, and effectiveness.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each 100 ml of solution contains:

• Mannitol 20 g

• Water for Injection q.s.

The solution is sterile, non-pyrogenic, and intended for intravenous infusion only.

Therapeutic Class

• Osmotic diuretic

• Intravenous infusion

Indications

Acme's Mannitol Injection 20% is indicated for:

• Reduction of raised intracranial pressure and cerebral edema

• Lowering elevated intraocular pressure before ophthalmic procedures

• Promotion of diuresis in acute renal failure

• Prevention and treatment of acute kidney injury in selected cases

• Enhancement of urinary excretion of toxic substances

It is commonly used in neurosurgical, ophthalmic, and critical care settings under close medical supervision.

Pharmacological Action

Mannitol is a non-metabolizable sugar alcohol that acts as an osmotic diuretic. When administered intravenously, it increases plasma osmolarity, drawing water from tissues into the intravascular compartment. This action helps reduce cerebral and ocular edema.

In the kidneys, mannitol is freely filtered by the glomeruli and not reabsorbed by the renal tubules. It increases osmotic pressure within the renal tubules, thereby inhibiting water reabsorption and promoting increased urine output. This diuretic effect helps flush the kidneys and maintain renal function in specific clinical situations.

Dosage and Administration

The dosage and infusion rate of Acme's Mannitol Injection 20% depend on the patient’s age, body weight, clinical condition, and therapeutic indication. Administration must be carried out by trained healthcare professionals. Adequate hydration and continuous monitoring of renal function, fluid balance, serum electrolytes, and serum osmolality are essential during therapy.

Precautions and Warnings

• For intravenous use only under strict medical supervision.

• Contraindicated in patients with severe dehydration, anuria, active intracranial bleeding, or severe pulmonary congestion.

• Use with caution in patients with impaired renal function or heart failure.

• Rapid infusion may cause fluid and electrolyte imbalance or circulatory overload.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Possible adverse effects include:

• Electrolyte imbalance

• Dehydration

• Headache, nausea, or vomiting

• Fluid overload and pulmonary edema in susceptible patients

• Local infusion site reactions

If adverse reactions occur, the infusion should be adjusted or discontinued as advised by a physician.

Storage

Store below 30°C in a cool, dry place. Protect from freezing and direct sunlight. Do not use if the solution is cloudy or crystals persist after warming to room temperature.