A-Fenac Suppository 50 mg contains Diclofenac Sodium, a potent nonsteroidal anti-inflammatory drug (NSAID) widely used for its analgesic, anti-inflammatory, and antipyretic properties. This rectal dosage form is particularly beneficial for patients who cannot tolerate oral medications due to gastrointestinal disturbances, vomiting, post-operative conditions, or difficulty swallowing. The suppository formulation ensures reliable absorption and effective pain control while reducing direct gastric irritation.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

A-Fenac Suppository 50 mg is indicated for the treatment of mild to moderate pain and inflammatory conditions, including:

• Acute and chronic musculoskeletal pain

• Post-operative and post-traumatic pain

• Pain associated with orthopedic, gynecological, or dental procedures

• Acute inflammatory conditions of the ear, nose, and throat

• Renal colic and biliary colic

• Pain and inflammation associated with arthritis

• Fever where oral administration is not feasible

It is suitable for use in adults and adolescents as prescribed by a physician.

Therapeutic Class

Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

Pharmacology

Diclofenac Sodium exerts its therapeutic effect by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins are key mediators of pain, inflammation, and fever. By reducing prostaglandin production, diclofenac effectively alleviates these symptoms.

Following rectal administration, diclofenac is absorbed through the rectal mucosa into the systemic circulation. This route partially bypasses first-pass hepatic metabolism, resulting in effective plasma concentrations. Diclofenac is extensively bound to plasma proteins and is metabolized primarily in the liver. The metabolites are excreted mainly via urine, with a smaller portion eliminated in bile. The elimination half-life allows convenient dosing while maintaining therapeutic efficacy.

Mechanism of Action

A-Fenac Suppository 50 mg works by blocking the production of inflammatory mediators at the site of tissue injury. This action leads to significant reduction in pain, swelling, and inflammation, along with effective control of fever.

Dosage and Administration

• Adults: One suppository (50 mg) once or twice daily, or as directed by a physician

• Adolescents: Dose should be adjusted according to body weight and clinical condition

The suppository should be inserted rectally, preferably after bowel evacuation. It should be used for the shortest duration necessary to control symptoms.

Drug Interactions

Diclofenac may interact with anticoagulants, antiplatelet agents, corticosteroids, other NSAIDs, antihypertensive drugs, diuretics, lithium, and methotrexate. Such combinations may increase the risk of gastrointestinal bleeding or renal impairment and should be used with caution.

Contraindications

A-Fenac Suppository 50 mg is contraindicated in patients with:

• Known hypersensitivity to diclofenac or other NSAIDs

• History of NSAID-induced bronchospasm, asthma, or allergic reactions

• Active peptic ulcer disease or gastrointestinal bleeding

• Severe hepatic, renal, or cardiac disorders

• Proctitis or other inflammatory rectal conditions

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Possible side effects include:

• Rectal irritation or discomfort

• Gastrointestinal symptoms such as nausea or abdominal pain

• Headache or dizziness

Serious adverse effects are uncommon when used at recommended doses for a short duration.

Use in Pregnancy and Lactation

Diclofenac is contraindicated during the third trimester of pregnancy and should be used with caution during earlier stages only if clearly needed. Use during breastfeeding should be under medical advice.

Storage Conditions

Store below 30°C in a cool and dry place. Protect from heat and light. Keep out of reach of children.