Yonex Injection 2 MIU (68 mg) contains Colistimethate Sodium, a potent polymyxin antibiotic used for the treatment of serious and life-threatening infections caused by multidrug-resistant Gram-negative bacteria. It is typically reserved for hospital and intensive care unit settings where other antibiotics have failed or are not suitable.

Colistimethate Sodium is a prodrug that is converted in the body into colistin, the active antibacterial compound. Colistin works by disrupting the bacterial cell membrane, leading to leakage of intracellular contents and rapid bacterial cell death. It is particularly effective against resistant organisms such as Pseudomonas aeruginosa, Acinetobacter species, and Klebsiella pneumoniae.

Yonex Injection 2 MIU is commonly used in moderate to severe infections or as part of combination therapy, with dosing adjusted carefully according to the patient’s condition, body weight, and kidney function.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each vial contains:

• Colistimethate Sodium USP 2 MIU (equivalent to 68 mg)

Indications

Yonex Injection is indicated for:

• Multidrug-resistant Gram-negative bacterial infections
• Hospital-acquired pneumonia (HAP)
• Ventilator-associated pneumonia (VAP)
• Sepsis and bloodstream infections
• Complicated urinary tract infections
• Intra-abdominal infections
• Other severe systemic infections when alternative antibiotics are ineffective

How It Works

Colistimethate Sodium is converted to colistin in the body. Colistin binds to lipopolysaccharides in the outer membrane of Gram-negative bacteria, disrupting membrane integrity and causing bacterial cell death.

Dosage and Administration

Yonex Injection should be administered only by qualified healthcare professionals.

• Given by intravenous infusion or intramuscular injection
• Dose is individualized based on infection severity, body weight, and renal function
• Requires dose adjustment in kidney impairment
• Continuous monitoring of kidney function is essential during therapy

Benefits of Yonex Injection

• Effective against multidrug-resistant Gram-negative infections
• Important option in critical care and ICU settings
• Useful when first-line antibiotics are ineffective
• Provides strong bactericidal activity
• Supports treatment of life-threatening infections

Precautions

Use cautiously in:

• Renal impairment (high risk of nephrotoxicity)
• Neuromuscular disorders
• Elderly patients
• Concomitant use of other nephrotoxic drugs
• Pregnancy and breastfeeding only if clearly necessary

Regular monitoring of renal and neurological status is required during therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Kidney toxicity (increased creatinine levels)
• Nausea and vomiting
• Dizziness
• Tingling or numbness
• Muscle weakness
• Injection site reactions

Serious adverse effects require immediate medical attention.

Storage

• Store below 25–30°C
• Protect from light
• Keep out of reach of children.