Xelmet XR Tablet 1000 mg contains Metformin Hydrochloride in an extended-release (XR) formulation designed to provide steady, long-lasting blood glucose control throughout the day. It is used in the management of type 2 diabetes mellitus and helps improve glycemic control while minimizing gastrointestinal side effects commonly associated with immediate-release Metformin.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Xelmet XR Tablet 1000 mg is indicated for:

• Management of type 2 diabetes mellitus in adults
• Maintenance therapy for patients requiring stable long-term glucose control
• Combination therapy with other oral antidiabetic agents or insulin
• Management of insulin resistance conditions such as polycystic ovary syndrome (PCOS), as prescribed by a physician

Mechanism of Action

Metformin XR works through multiple complementary mechanisms:

• Reduces hepatic glucose production (gluconeogenesis)
• Increases peripheral glucose uptake and insulin sensitivity
• Enhances glucose utilization in muscle tissues
• Decreases intestinal absorption of glucose

The extended-release formulation allows gradual absorption of the drug, maintaining consistent plasma levels and improving tolerability.

Dosage and Administration

• Dosage is individualized based on blood glucose levels and clinical response
• Usually taken once daily with the evening meal
• Swallow the tablet whole; do not crush, chew, or split
• Regular monitoring of blood glucose and kidney function is recommended
• Dose adjustment may be required based on therapeutic response

Benefits

• Provides smooth and sustained 24-hour blood glucose control
• Once-daily dosing improves patient compliance
• Lower risk of gastrointestinal side effects compared to immediate-release formulations
• Helps control both fasting and post-meal blood sugar levels
• Low risk of hypoglycemia when used alone

Side Effects

Common side effects may include:

• Nausea
• Diarrhea
• Abdominal discomfort
• Flatulence
• Reduced appetite

Rare but serious side effect:

• Lactic acidosis, particularly in patients with renal or hepatic impairment

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use cautiously in patients with kidney or liver disease
• Avoid excessive alcohol intake during treatment
• Temporary discontinuation may be required before imaging procedures using iodinated contrast
• Not recommended in severe renal impairment
• Regular monitoring of renal function is essential

Storage

• Store below 25°C
• Protect from moisture and heat
• Keep out of reach of children.