Vorifast Tablet 200 mg contains Voriconazole, a broad-spectrum triazole antifungal medicine used for the treatment of serious fungal infections. It is particularly effective against invasive fungal infections caused by Aspergillus species and other susceptible fungi. Voriconazole is commonly prescribed in hospitalized or immunocompromised patients, such as those undergoing chemotherapy, organ transplantation, or suffering from severe immune suppression.

Voriconazole works by inhibiting fungal cytochrome P450-dependent enzyme lanosterol 14-α-demethylase. This enzyme is essential for the synthesis of ergosterol, a key component of fungal cell membranes. By blocking ergosterol production, Voriconazole disrupts the structure and function of fungal cells, leading to their death and preventing further growth and spread of infection.

Vorifast Tablet is considered a first-line treatment for invasive aspergillosis and is also used for serious Candida infections, esophageal candidiasis, and infections caused by Scedosporium and Fusarium species. Due to its potent antifungal activity, it is reserved for moderate to severe infections and should only be used under strict medical supervision.

The dosage and duration of treatment depend on the type and severity of infection, patient response, and liver function status. Regular monitoring is important during therapy to ensure safety and effectiveness.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each film-coated tablet contains:

• Voriconazole BP 200 mg

Indications

Vorifast Tablet is indicated for:

• Invasive aspergillosis
• Serious Candida infections
• Esophageal candidiasis
• Scedosporium infections
• Fusarium infections
• Severe or systemic fungal infections in immunocompromised patients

How It Works

Voriconazole inhibits fungal ergosterol synthesis by blocking lanosterol 14-α-demethylase. This disrupts fungal cell membrane integrity, leading to inhibition of fungal growth and eventual cell death.

Dosage and Administration

The dosage should be strictly followed as prescribed by a registered physician.

• Usually administered twice daily after a loading dose (as directed by the physician)
• Should be taken on an empty stomach or as advised
• Treatment duration varies depending on infection severity and clinical response

Benefits of Vorifast Tablet

• Effective against a wide range of serious fungal infections
• First-line treatment for invasive aspergillosis
• Useful in immunocompromised patients
• Helps prevent spread of systemic fungal infections
• Strong and targeted antifungal action

Precautions

Use cautiously in:

• Patients with liver impairment
• Patients with heart rhythm disorders (QT prolongation risk)
• Kidney impairment (especially injectable forms if used)
• Pregnant or breastfeeding women unless clearly necessary

Regular liver function tests and clinical monitoring are recommended during treatment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Nausea and vomiting
• Visual disturbances (blurred vision, altered color perception)
• Headache
• Rash
• Abdominal pain
• Elevated liver enzymes
• Dizziness

Serious side effects such as severe liver toxicity, allergic reactions, or cardiac rhythm disturbances require immediate medical attention.

Storage

• Store below 30°C
• Protect from light and moisture
• Keep out of reach of children.