Vorifast Suspension 200 mg/5 ml contains Voriconazole, a broad-spectrum triazole antifungal medicine used for the treatment of serious fungal infections in patients who require an oral liquid formulation. It is commonly prescribed for invasive aspergillosis, serious Candida infections, and other systemic fungal diseases, especially in pediatric patients or adults who have difficulty swallowing tablets.

Voriconazole works by inhibiting the fungal cytochrome P450 enzyme lanosterol 14-α-demethylase. This enzyme is essential for producing ergosterol, a key structural component of fungal cell membranes. By blocking ergosterol synthesis, Voriconazole disrupts fungal cell membrane integrity, leading to inhibition of fungal growth and eventual death of the fungus.

Vorifast Suspension provides effective systemic antifungal action and is often used in hospital and outpatient settings under strict medical supervision. It may be used as initial therapy or continued after injectable treatment depending on the patient’s condition and clinical response. The liquid formulation allows flexible dosing, making it suitable for children and patients requiring individualized dose adjustments.

Due to its potent antifungal activity and potential for drug interactions, Voriconazole therapy requires careful monitoring. Liver function tests and clinical response should be regularly assessed during treatment to ensure safety and effectiveness.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each 5 ml suspension contains:

• Voriconazole BP 200 mg

Indications

Vorifast Suspension is indicated for:

• Invasive aspergillosis
• Serious Candida infections
• Esophageal candidiasis (when oral solid dosage form is not suitable)
• Scedosporium infections
• Fusarium infections
• Systemic fungal infections in immunocompromised patients
• Pediatric fungal infections requiring oral suspension

How It Works

Voriconazole inhibits lanosterol 14-α-demethylase, preventing the synthesis of ergosterol in fungal cell membranes. This leads to weakened cell structure, impaired fungal growth, and eventual fungal cell death.

Dosage and Administration

The dosage should always be determined by a registered physician.

• Dose varies based on body weight, age, and severity of infection
• Usually administered twice daily after an initial loading regimen (as prescribed)
• Shake well before use
• Use a proper measuring device for accurate dosing
• Follow strict medical supervision during therapy

Benefits of Vorifast Suspension

• Effective against serious systemic fungal infections
• Suitable for pediatric and adult patients needing liquid formulation
• Allows flexible and precise dosing
• Useful in patients unable to swallow tablets
• Strong antifungal activity with systemic effect

Precautions

Use cautiously in:

• Patients with liver impairment
• Patients with heart rhythm disorders (QT prolongation risk)
• Kidney impairment (monitor closely during treatment)
• Pregnant or breastfeeding women unless clearly necessary

Regular monitoring of liver enzymes and possible drug interactions is essential during therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Nausea and vomiting
• Headache
• Fever
• Visual disturbances (blurred vision, altered color perception)
• Abdominal pain
• Skin rash
• Elevated liver enzymes

Serious adverse effects require immediate medical attention.

Storage

• Store below 30°C
• Protect from light and moisture
• Keep tightly closed after use
• Keep out of reach of children.