Vesinac Tablet 10 mg is an oral antimuscarinic medication containing Solifenacin Succinate, indicated for the effective management of symptoms associated with overactive bladder (OAB). This higher-strength formulation is intended for patients who require enhanced symptom control when lower doses are insufficient. By reducing involuntary bladder contractions, Vesinac 10 mg helps restore normal urinary patterns and improves daily comfort and confidence.

Solifenacin Succinate selectively inhibits muscarinic M3 receptors located in the detrusor muscle of the urinary bladder. These receptors play a key role in bladder contractions during the storage and voiding phases. By blocking their action, Vesinac increases functional bladder capacity and reduces episodes of urgency, frequency, and urge urinary incontinence. Its long duration of action supports convenient once-daily dosing, promoting better treatment adherence.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Antimuscarinic

• Urinary Antispasmodic

Indications

Vesinac Tablet 10 mg is indicated for the treatment of symptoms of overactive bladder in adult patients, including:

• Urinary urgency

• Increased frequency of urination

• Urge urinary incontinence

This strength is commonly prescribed for patients who do not achieve adequate symptom relief with the 5 mg dose.

Pharmacology

Solifenacin Succinate is a competitive antagonist of muscarinic receptors with relative selectivity for the M3 subtype. After oral administration, it is well absorbed and extensively metabolized in the liver, mainly by the CYP3A4 enzyme system. Solifenacin has a prolonged elimination half-life, allowing steady plasma concentrations with once-daily dosing. The drug and its metabolites are eliminated via both renal and fecal routes.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

The usual recommended dose of Vesinac Tablet 10 mg is 10 mg once daily, taken orally with or without food. Tablets should be swallowed whole with water and should not be crushed or chewed.

Dose adjustments may be required in patients with severe renal impairment or moderate hepatic impairment. Vesinac should be used cautiously and only under medical supervision in such cases.

Drug Interactions

Caution is advised when Vesinac is co-administered with strong CYP3A4 inhibitors, as these may increase Solifenacin plasma levels. Concurrent use with other anticholinergic agents may enhance antimuscarinic side effects such as dry mouth, constipation, or blurred vision.

Contraindications

Vesinac Tablet 10 mg is contraindicated in patients with:

• Urinary retention

• Gastric retention

• Uncontrolled narrow-angle glaucoma

• Known hypersensitivity to Solifenacin Succinate or any excipients

Side Effects

Common side effects include dry mouth, constipation, blurred vision, nausea, and dizziness. Less frequent effects may include urinary retention, abdominal discomfort, and fatigue. Most adverse reactions are mild to moderate and related to anticholinergic activity.

Precautions and Warnings

Caution should be exercised in patients with bladder outflow obstruction, gastrointestinal obstructive disorders, or reduced gastrointestinal motility. Patients should be advised about possible visual disturbances and reduced alertness during treatment.

Pregnancy and Lactation

There is limited clinical data on the use of Solifenacin during pregnancy. Vesinac should be used only if clearly needed. Caution is recommended during breastfeeding, as it is not known whether Solifenacin is excreted in human milk.

Storage Conditions

Store in a cool, dry place away from light and moisture. Keep out of the reach of children.