Trucef Suspension 20 mg/ml contains Cefpodoxime Proxetil, a third-generation cephalosporin antibiotic designed for the effective treatment of a wide range of bacterial infections in infants, children, adolescents, and adults. Its broad antibacterial spectrum, stability against many beta-lactamase enzymes, and convenient oral suspension form make it a reliable option in daily clinical practice.

Cefpodoxime Proxetil is a prodrug that is converted in the body to its active form, Cefpodoxime, after oral administration. It works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death. Trucef is effective against both Gram-positive and Gram-negative organisms and is often prescribed when the causative organism is suspected but not yet identified.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Third Generation Cephalosporin Antibiotic

Indications

Trucef Suspension is indicated for the treatment of infections caused by susceptible microorganisms, including:

• Acute otitis media caused by Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Moraxella catarrhalis (including beta-lactamase producing strains)

• Pharyngitis and tonsillitis caused by Streptococcus pyogenes

• Acute maxillary sinusitis caused by Haemophilus influenzae (including beta-lactamase producing strains), Streptococcus pneumoniae, and Moraxella catarrhalis

• Community-acquired pneumonia caused by Streptococcus pneumoniae or Haemophilus influenzae

• Acute bacterial exacerbation of chronic bronchitis

• Skin and skin structure infections caused by Staphylococcus aureus and Streptococcus pyogenes

• Uncomplicated urinary tract infections caused by E. coli, Klebsiella pneumoniae, Proteus mirabilis, or Staphylococcus saprophyticus

• Uncomplicated gonorrhea and rectal gonococcal infections in women caused by Neisseria gonorrhoeae, including penicillinase-producing strains

Pharmacology

Cefpodoxime is an orally active third-generation cephalosporin with good stability against beta-lactamase enzymes. After absorption, Cefpodoxime Proxetil is rapidly converted to Cefpodoxime. Approximately 29–33% of the drug is excreted unchanged in the urine within 12 hours, making it effective for urinary tract infections.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

Adults and Adolescents (13 years and older):

• Pharyngitis/Tonsillitis: 100 mg every 12 hours for 5–10 days

• Acute maxillary sinusitis: 200 mg every 12 hours for 10 days

• Community-acquired pneumonia: 200 mg every 12 hours for 14 days

• Acute exacerbation of chronic bronchitis: 200 mg every 12 hours for 10 days

• Skin and skin structure infections: 400 mg every 12 hours for 7–14 days

• Uncomplicated UTI: 100 mg every 12 hours for 7 days

• Uncomplicated gonorrhea and rectal gonococcal infections: single 200 mg dose

Infants and Pediatric Patients (2 months to 12 years):

• Acute otitis media: 5 mg/kg every 12 hours for 5 days

• Pharyngitis/Tonsillitis: 5 mg/kg every 12 hours for 5–10 days

• Acute maxillary sinusitis: 5 mg/kg every 12 hours for 10 days

Dosage should be adjusted in patients with severe renal impairment.

Drug Interactions

High doses of antacids or H2 blockers may reduce absorption of Cefpodoxime. Probenecid can inhibit renal excretion and increase plasma levels of the drug.

Contraindications

Trucef Suspension is contraindicated in patients with known hypersensitivity to cephalosporins.

Side Effects

Cefpodoxime is generally well tolerated. Possible side effects include diarrhea, nausea, vomiting, abdominal pain, rash, urticaria, and itching.

Pregnancy and Lactation

Cefpodoxime is classified as US FDA Pregnancy Category B. It should be used during pregnancy only if clearly needed. As it is excreted in breast milk, caution is advised during breastfeeding.

Storage Conditions

Store in a dry place away from light and heat. Keep out of the reach of children.

Reconstitution

Shake the bottle well to loosen the powder. Add boiled and cooled water up to the marked level and shake until the powder is completely mixed.