Vercef DS Suspension 80 mg/5 ml is a double-strength oral antibiotic formulation containing Cefpodoxime Proxetil, a third-generation cephalosporin widely used for the treatment of a broad range of bacterial infections. This suspension is specially designed to provide higher potency per dose, making it particularly suitable for pediatric patients requiring larger doses and for situations where accurate dosing and strong antibacterial coverage are essential.

Cefpodoxime Proxetil is a prodrug that is converted in vivo to its active form, Cefpodoxime, after oral administration. It exerts its antibacterial effect by inhibiting bacterial cell wall synthesis, leading to rapid bacterial cell death. Vercef DS demonstrates strong activity against both Gram-positive and Gram-negative organisms and shows good stability against many beta-lactamase–producing bacteria, enhancing its clinical reliability.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Third Generation Cephalosporin Antibiotic

Indications

Vercef DS Suspension is indicated for the treatment of infections caused by susceptible microorganisms, including:

• Acute otitis media caused by Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Moraxella catarrhalis (including beta-lactamase–producing strains)

• Pharyngitis and tonsillitis caused by Streptococcus pyogenes

• Acute maxillary sinusitis caused by Haemophilus influenzae (including beta-lactamase–producing strains), Streptococcus pneumoniae, and Moraxella catarrhalis

• Community-acquired pneumonia caused by Streptococcus pneumoniae or Haemophilus influenzae (including beta-lactamase–producing strains)

• Acute bacterial exacerbation of chronic bronchitis

• Skin and skin structure infections caused by Staphylococcus aureus and Streptococcus pyogenes

• Uncomplicated urinary tract infections caused by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, or Staphylococcus saprophyticus

• Uncomplicated gonorrhea and rectal gonococcal infections in women caused by Neisseria gonorrhoeae, including penicillinase-producing strains

Pharmacology

Cefpodoxime is an orally active third-generation cephalosporin with a broad antibacterial spectrum and good resistance to beta-lactamase enzymes. Following oral administration, Cefpodoxime Proxetil is rapidly absorbed and converted to Cefpodoxime. Approximately 29–33% of the drug is excreted unchanged in the urine within 12 hours, contributing to its effectiveness in urinary tract infections.

Dosage and Administration

Adults and Adolescents (13 years and older):

• Pharyngitis/Tonsillitis: 100 mg every 12 hours for 5–10 days

• Acute maxillary sinusitis: 200 mg every 12 hours for 10 days

• Community-acquired pneumonia: 200 mg every 12 hours for 14 days

• Acute bacterial exacerbation of chronic bronchitis: 200 mg every 12 hours for 10 days

• Skin and skin structure infections: 400 mg every 12 hours for 7–14 days

• Uncomplicated UTI: 100 mg every 12 hours for 7 days

• Uncomplicated gonorrhea and rectal gonococcal infections: single 200 mg dose

Infants and Pediatric Patients (2 months to 12 years):

• Acute otitis media: 5 mg/kg body weight every 12 hours for 5 days

• Pharyngitis/Tonsillitis: 5 mg/kg body weight every 12 hours for 5–10 days

• Acute maxillary sinusitis: 5 mg/kg body weight every 12 hours for 10 days

Dosage adjustment is required in patients with severe renal impairment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Concomitant use of high-dose antacids or H2 blockers may reduce the absorption of Cefpodoxime. Probenecid may inhibit renal excretion and increase plasma concentrations.

Contraindications

Vercef DS is contraindicated in patients with known hypersensitivity to cephalosporins.

Side Effects

The drug is generally well tolerated. Possible side effects include diarrhea, nausea, vomiting, abdominal pain, rash, urticaria, and itching.

Pregnancy and Lactation

Cefpodoxime is classified as US FDA Pregnancy Category B. It should be used during pregnancy only if clearly necessary. As it is excreted in breast milk, caution is advised during lactation.

Storage and Reconstitution

Store in a dry place away from light and heat. Keep out of the reach of children.
To reconstitute, shake the bottle to loosen the powder, add boiled and cooled water up to the marked level, and shake well until fully mixed.