Veracal Tablet 80 mg contains Verapamil Hydrochloride, a well-established calcium channel blocker used in the management of various cardiovascular conditions. It is effective in controlling blood pressure, relieving angina symptoms, and regulating abnormal heart rhythms. By acting directly on the heart and blood vessels, Veracal 80 mg helps improve cardiac efficiency and reduces cardiovascular complications.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Calcium-channel blockers

Pharmacology

Verapamil inhibits the entry of calcium ions into slow calcium channels and voltage-sensitive areas of vascular smooth muscle and myocardial cells during depolarization. This action results in relaxation of coronary and peripheral vascular smooth muscle, leading to coronary vasodilation and improved myocardial oxygen delivery. Verapamil also suppresses automaticity and slows atrioventricular (AV) node conduction, making it particularly effective in managing supraventricular arrhythmias. These combined effects reduce heart rate, myocardial oxygen demand, and systemic blood pressure.

Indications

Veracal Tablet 80 mg is indicated for the treatment of:

• Essential hypertension

• Angina pectoris and prevention of re-infarction

• Supraventricular arrhythmias

Verapamil injection (where applicable) is additionally used in:

• Paroxysmal supraventricular tachycardia

• Atrial fibrillation with rapid ventricular response (except in WPW syndrome)

• Atrial flutter with rapid conduction

• Extrasystoles

• Acute hypertension and acute coronary insufficiency

• Prophylaxis and treatment of ectopic arrhythmias, particularly ventricular extrasystoles during halothane anesthesia or adrenaline use

Dosage and Administration

The dosage of Veracal 80 mg should be individualized by careful titration and administered with food.

For essential hypertension, the usual initial dose is 180 mg once daily in the morning. If adequate control is not achieved, the dose may be adjusted to:

• 240 mg once daily

• 180 mg in the morning plus 180 mg in the evening

• 240 mg every 12 hours

For angina pectoris, the usual dose ranges from 80 mg to 120 mg three times daily.
For arrhythmias in digitalized patients, 240 mg to 360 mg daily in divided doses may be required, depending on severity.

All dosage adjustments should be made under medical supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Verapamil may interact with several medications. Plasma levels may increase with CYP3A4 inhibitors such as erythromycin, ritonavir, and cimetidine, and decrease with inducers like rifampicin and phenobarbital. Verapamil may enhance the effects of beta-blockers, digoxin, antihypertensives, and diuretics, increasing the risk of bradycardia or hypotension. It may also increase plasma concentrations of statins, immunosuppressants, lithium, and other commonly used drugs.

Contraindications

Veracal Tablet 80 mg is contraindicated in patients with:

• Severe left ventricular dysfunction

• Hypotension or cardiogenic shock

• Sick sinus syndrome (without a pacemaker)

• Second- or third-degree AV block (without a pacemaker)

• Atrial fibrillation or flutter with accessory pathways such as WPW syndrome

• Known hypersensitivity to verapamil

Side Effects

Verapamil is generally well tolerated. Common side effects include constipation, nausea, dizziness, headache, hypotension, bradycardia, edema, fatigue, rash, and transient elevation of liver enzymes.

Pregnancy and Lactation

Verapamil should be used during pregnancy only if clearly necessary, as it may cause fetal hypoxia due to maternal hypotension. It is excreted in breast milk; therefore, breastfeeding should be discontinued during treatment.

Storage

Store below 30°C, protected from light and moisture. Keep out of reach of children.