Velsovir Tablet 400 mg + 100 mg is a combination antiviral medication containing Sofosbuvir and Velpatasvir, used for the treatment of chronic Hepatitis C virus (HCV) infection in adults. This combination therapy is effective against all major HCV genotypes, making it a pan-genotypic option for patients with chronic Hepatitis C.

The combination works by targeting two critical proteins involved in HCV replication. Sofosbuvir inhibits the NS5B polymerase enzyme, preventing viral RNA synthesis, while Velpatasvir inhibits the NS5A protein, which is essential for viral replication and assembly. Together, they provide a potent antiviral effect, leading to sustained virologic response (SVR) and clearance of the virus in most patients.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Sofosbuvir 400 mg

• Velpatasvir 100 mg

Mechanism of Action

• Sofosbuvir: A nucleotide analog that inhibits HCV NS5B RNA-dependent RNA polymerase, blocking viral RNA replication.

• Velpatasvir: A NS5A inhibitor that disrupts viral replication and assembly.

The dual mechanism ensures comprehensive inhibition of viral replication and helps achieve high cure rates with a short treatment duration.

Indications

Velsovir Tablet 400 mg + 100 mg is indicated for:

• Chronic Hepatitis C infection in adults

• Patients with any HCV genotype (pan-genotypic)

• Compensated liver disease (including cirrhosis)

This therapy may be used in patients with or without prior treatment experience.

Dosage and Administration

• Recommended dose: 1 tablet orally once daily, with or without food

• Treatment duration is typically 12 weeks, but may vary based on clinical assessment

• Tablets should be swallowed whole with water

• Consistent daily intake is crucial for optimal viral clearance

Dosage adjustments may be necessary for patients with severe liver impairment; consult a healthcare professional before use.

Benefits of Velsovir Tablet

• Highly effective against all HCV genotypes

• Oral administration with once-daily dosing

• High rates of sustained virologic response (SVR)

• Well-tolerated with fewer side effects compared to older interferon-based therapies

• Can be used in patients with compensated liver disease

Possible Side Effects

Velsovir is generally well-tolerated. Some patients may experience mild side effects:

• Headache

• Fatigue

• Nausea

• Diarrhea

• Insomnia

Serious side effects are rare, but patients should seek medical attention if they experience severe allergic reactions or signs of liver dysfunction.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use only under medical supervision

• Not recommended for patients with severe liver impairment without specialist guidance

• Inform your doctor about other medications to avoid drug interactions

• Pregnancy and breastfeeding: consult a doctor before use

• Regular monitoring of liver function and viral load is advised

Storage

Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.

Velsovir Tablet 400 mg + 100 mg offers a safe, effective, and convenient oral therapy for chronic Hepatitis C. With consistent use, it provides high cure rates and improves liver health and patient quality of life.