Diretic-DS Tablet 40 mg+50 mg is a potent combination diuretic containing Furosemide 40 mg and Spironolactone 50 mg, formulated for the treatment of fluid retention and hypertension. This dual-action tablet combines a loop diuretic (Furosemide) and a potassium-sparing diuretic (Spironolactone) to provide effective removal of excess fluid from the body while helping maintain potassium balance.

Furosemide works primarily on the loop of Henle in the kidneys, increasing the excretion of sodium, chloride, and water, which reduces edema and lowers blood pressure. Spironolactone acts on the distal renal tubules by antagonizing aldosterone, promoting sodium and water excretion while retaining potassium, which minimizes the risk of hypokalemia commonly seen with high-dose loop diuretics. Together, this combination provides synergistic diuretic activity, offering rapid and sustained control of fluid overload.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Diretic-DS Tablet 40 mg+50 mg is indicated for:

• Management of edema associated with congestive heart failure, liver cirrhosis, or nephrotic syndrome

• Treatment of hypertension, particularly in patients requiring potent diuretic therapy

• Reduction of fluid accumulation in ascites due to liver disease

• Prevention of potassium depletion in patients on high-dose loop diuretics

• Management of fluid retention in chronic kidney disease (under physician supervision)

This combination is particularly useful in patients requiring both strong diuresis and electrolyte balance.

Dosage and Administration

• Adults: Usually, one tablet daily or as prescribed by a healthcare professional, based on the patient’s condition and fluid status.

• Administration: Swallow the tablet whole with water, preferably in the morning to reduce nocturnal urination.

• Dose adjustments may be necessary for patients with renal or hepatic impairment.

• Regular monitoring of blood pressure, electrolytes, and kidney function is recommended during therapy.

Patients are advised to maintain an adequate fluid intake unless otherwise instructed and avoid excessive salt consumption, which can reduce the effectiveness of the medication.

Precautions

• Contraindicated in patients with anuria, severe kidney impairment, hyperkalemia, or hypersensitivity to Furosemide, Spironolactone, or any tablet component.

• Use cautiously in patients with liver or kidney disease, diabetes, or heart rhythm abnormalities.

• Monitor potassium, sodium, and renal function regularly to prevent electrolyte imbalances.

• May interact with other medications such as ACE inhibitors, ARBs, potassium supplements, or other diuretics. Consult your physician before combining therapies.

• Pregnant or breastfeeding women should only use under strict medical supervision.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Diretic-DS Tablet is generally well tolerated, but some patients may experience:

• Electrolyte imbalances (hyperkalemia, hyponatremia)

• Increased urination, dehydration, or dizziness

• Hypotension or fainting

• Gastrointestinal upset such as nausea or abdominal discomfort

• Rarely, allergic reactions, skin rash, or gynecomastia (related to Spironolactone)

Immediate medical attention is required if severe dehydration, irregular heartbeat, or signs of electrolyte imbalance occur.

Storage

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.

Diretic-DS Tablet 40 mg+50 mg provides effective management of edema and hypertension, combining the rapid diuretic action of Furosemide with the potassium-sparing benefits of Spironolactone, ensuring balanced fluid and electrolyte control under medical supervision.