Vastigro 3 mg is a prescription medication used for the symptomatic treatment of mild to moderately severe Alzheimer's dementia and dementia associated with idiopathic Parkinson's disease. It belongs to the therapeutic class of drugs for dementia and works by enhancing cholinergic activity in the brain.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class:
Drugs for Dementia

Mechanism of Action:
Vastigro contains Rivastigmine, a carbamate derivative structurally related to physostigmine. Rivastigmine acts as a reversible cholinesterase inhibitor, targeting acetylcholinesterase and butyrylcholinesterase in the brain. By preventing the breakdown of acetylcholine, it increases the concentration of this neurotransmitter at cholinergic synapses, improving cognitive function in affected patients. Its action is relatively specific to the central nervous system compared with peripheral tissues.

Indications:

• Symptomatic treatment of mild to moderately severe Alzheimer's dementia

• Symptomatic treatment of mild to moderately severe dementia in Parkinson’s disease

Dosage & Administration:

• Oral Capsules:

  • Initial dose: 1.5 mg twice daily

  • Dose titration: Increase to 3 mg twice daily after 2 weeks if tolerated; further increments to 4.5 mg and 6 mg twice daily based on tolerability

  • Maintenance dose: 3 mg to 6 mg twice daily; continue at the highest tolerated dose for maximum benefit

  • If treatment is interrupted for several days, restart at 1.5 mg twice daily

• Transdermal Patch:

  • Initial dose: 4.6 mg/24 hours

  • Increase to 9.5 mg/24 hours after 4 weeks if tolerated

  • Maximum dose: 13.3 mg/24 hours

• Administer capsules twice daily with morning and evening meals

• Replace transdermal patch every 24 hours

Interactions:

• May enhance effects of succinylcholine-type muscle relaxants during anesthesia

• Avoid concomitant use with other cholinomimetic drugs

• No significant pharmacokinetic interactions with digoxin, warfarin, diazepam, or fluoxetine

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications:

• Hypersensitivity to Rivastigmine or other carbamate derivatives

Side Effects:

• Common: Nausea (38%), vomiting (23%), and weight loss

• Gastrointestinal side effects are more common in female patients

• Other: Bradycardia, syncope, exacerbation of extrapyramidal symptoms

Precautions & Warnings:

• Use with caution in patients with cardiac conduction defects, respiratory diseases, urinary obstruction, seizure disorders, asthma, or obstructive pulmonary disease

• Monitor weight, gastrointestinal symptoms, and cognitive response

• May worsen extrapyramidal symptoms in Parkinson’s disease

Pregnancy & Lactation:

• Safety in pregnancy not established; use only if clearly necessary

• Rivastigmine is excreted in milk in animals; breastfeeding is not recommended

Overdose:

• Symptoms: Nausea, vomiting, diarrhea, bradycardia, syncope, hallucinations

• Management: Symptomatic treatment; atropine may be used in severe cases

Storage:

• Store in a cool, dry place, protected from light