Trimotil Tablet contains Trimebutine Maleate, a spasmolytic agent used for the effective management of gastrointestinal motility disorders. It helps regulate abnormal intestinal movements without affecting normal gut function, making it especially useful in functional bowel conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Trimotil Tablet is indicated for:

• Treatment and symptomatic relief of irritable bowel syndrome (IBS)

• Management of postoperative paralytic ileus to accelerate the resumption of intestinal transit following abdominal surgery

Pharmacology

Trimebutine maleate is a non-competitive spasmolytic agent with:

• Modest affinity for opiate receptors

• Strong anti-serotonin activity, particularly on mu receptors

In experimental studies on isolated guinea pig colon and ileum, it has been shown to synchronize electrophysiological activity with intestinal contractions. Rather than altering normal motility, Trimebutine selectively modulates abnormal or disordered intestinal movements, thereby restoring functional balance in the gastrointestinal tract.

Dosage & Administration

• Adults: 100–200 mg (1–2 tablets), three times daily, preferably before meals

• Children: Not recommended for children under 12 years of age

Dosage should be adjusted according to clinical response and physician advice.

Drug Interactions

• Trimebutine maleate may increase the duration of d-tubocurarine-induced neuromuscular blockade

• No other clinically significant drug interactions have been reported in clinical trials

Contraindications

Trimotil Tablet is contraindicated in:

• Patients with known hypersensitivity to Trimebutine maleate or any of the excipients

Side Effects

Trimotil is generally well tolerated. Rarely reported adverse effects include:

Gastrointestinal

• Dry mouth

• Foul taste

• Diarrhea

• Dyspepsia

• Epigastric pain

• Nausea

• Constipation

Central Nervous System

• Drowsiness

• Fatigue

• Dizziness

• Headache

• Hot or cold sensations

Pregnancy & Lactation

• Animal studies have not demonstrated teratogenic effects; however, use during pregnancy is not recommended

• It is unknown whether Trimebutine passes into breast milk; therefore, it should be used during lactation only if the potential benefit justifies the possible risk to the infant.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions & Warnings

• Use with caution in pregnant or lactating women

• Special consideration is advised in elderly patients

Therapeutic Class

• Anticholinergics

Storage Conditions

• Store in a cool and dry place

• Protect from light and moisture

• Keep out of the reach of children.