Traneta 5 mg improves glycaemic control by inhibiting the enzyme DPP-4, which is responsible for the breakdown of incretin hormones such as GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). Inhibition of DPP-4 increases active incretin levels, resulting in glucose-dependent stimulation of insulin secretion from pancreatic beta cells and suppression of glucagon release from alpha cells. This mechanism helps lower blood glucose levels without causing excessive hypoglycaemia.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage & Administration

• Recommended dose: Traneta 5 mg once daily

• May be taken with or without food, at any time of the day

• When used with metformin, the metformin dose should be continued

• When combined with a sulphonylurea, a lower sulphonylurea dose may be considered to reduce the risk of hypoglycaemia

• Renal impairment: No dose adjustment is required

Dosage should be followed as prescribed by a registered physician.

Drug Interactions

Traneta 5 mg is a weak competitive and weak to moderate mechanism-based inhibitor of the CYP3A4 isoenzyme. Clinical studies have shown no clinically significant interactions with commonly used medicines, including:

• Metformin

• Glyburide

• Simvastatin

• Warfarin

• Digoxin

• Oral contraceptives

Clinically meaningful drug interactions are unlikely.

Contraindications

Traneta 5 mg is contraindicated in patients with:

• Known hypersensitivity to the active substance or any excipients of the formulation

Side Effects

Possible side effects may include:

• Hypoglycaemia (especially when used with metformin and sulphonylurea)

• Nasopharyngitis

• Cough

• Pancreatitis (rare)

Most adverse effects are mild to moderate in severity.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pregnancy & Lactation

• Pregnancy Category B: Adequate and well-controlled studies in pregnant women are lacking

• Traneta 5 mg should be used during pregnancy only if clearly needed

• It is unknown whether the drug is excreted in human breast milk; caution is advised during lactation

Precautions & Warnings

• Use with caution in patients with a history of hypersensitivity reactions

• Monitor patients for signs of pancreatitis

• Dose adjustments of concomitant antidiabetic agents may be required to avoid hypoglycaemia

Storage Conditions

• Store in a dry place

• Protect from heat and light

• Keep out of reach of children

Mode of Action

Traneta 5 mg inhibits the DPP-4 enzyme, increasing levels of active incretin hormones GLP-1 and GIP. This leads to enhanced glucose-dependent insulin secretion and reduced glucagon release, resulting in improved glycaemic control in patients with type 2 diabetes mellitus.