Teviral Tablet 1 mg contains Entecavir, a potent antiviral agent used for the treatment of chronic hepatitis B virus (HBV) infection. It belongs to the class of nucleoside analog reverse transcriptase inhibitors (NRTIs) and works by blocking HBV replication in liver cells. This higher-strength formulation is typically prescribed for patients with more active viral replication or those who have previously developed resistance to other antiviral therapies.

Entecavir helps reduce viral load, improve liver function, and prevent disease progression to cirrhosis or hepatocellular carcinoma, supporting long-term liver health.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Teviral Tablet 1 mg is indicated for:

• Chronic hepatitis B infection in adults and adolescents (≥16 years) with active viral replication
• Patients with prior lamivudine resistance
• Prevention of liver disease progression, including cirrhosis and hepatocellular carcinoma
• Treatment in patients with compensated or decompensated liver disease due to HBV

Mechanism of Action

Entecavir is a guanosine nucleoside analog that inhibits HBV DNA polymerase (reverse transcriptase). Its action involves:

• Blocking viral DNA synthesis
• Suppressing viral replication in hepatocytes
• Reducing liver inflammation and damage

The result is sustained viral suppression and improved liver function over time.

Dosage and Administration

• The standard dose for adults with lamivudine-resistant HBV is 1 mg once daily on an empty stomach (at least 2 hours before or after food).
• Duration of therapy depends on viral load, liver condition, and clinical response; long-term therapy may be required.
• Swallow the tablet whole with water; do not crush or chew.
• Dose adjustments may be required in patients with renal impairment.

Benefits

• Effective suppression of hepatitis B viral replication, including lamivudine-resistant strains
• Reduces liver inflammation and progression to fibrosis or cirrhosis
• Lowers risk of hepatocellular carcinoma
• Convenient once-daily oral administration
• Well-tolerated with minimal side effects in most patients

Side Effects

Common side effects may include:

• Headache
• Fatigue
• Nausea
• Dizziness

Serious but rare side effects:

• Lactic acidosis
• Severe liver problems
• Kidney function impairment
• Allergic reactions

Seek immediate medical attention if severe or unusual symptoms occur.

Precautions and Warnings

• Monitor liver and kidney function before and during therapy.
• Use caution in patients with pre-existing renal or hepatic impairment.
• Abrupt discontinuation may result in HBV flare; consult a physician before stopping therapy.
• Rare cases of lactic acidosis have been reported, especially in patients with liver disease.
• Pregnancy and breastfeeding should only use under medical supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Teviral Tablet may interact with:

• Other antiviral medications
• Nephrotoxic drugs (requires kidney monitoring)
• Drugs affecting liver metabolism

Inform your healthcare provider of all medications, supplements, and herbal products you are using.

Storage

• Store below 25°C in a cool, dry place
• Protect from light and moisture
• Keep out of reach of children.