Safina Tablet 50 mg contains Safinamide Mesylate, a modern adjunct therapy used in the management of Parkinson’s disease. It is prescribed alongside levodopa-based treatment to help reduce motor fluctuations, particularly “off” episodes when symptoms of Parkinson’s disease temporarily worsen. Safinamide improves motor control and supports better daily functioning in patients with Parkinson’s disease.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Safinamide Mesylate 50 mg

Indications

Safina Tablet 50 mg is indicated for:

• Adjunct treatment of Parkinson’s disease with levodopa/carbidopa
• Management of motor fluctuations (“wearing-off” effect)
• Improvement of movement symptoms such as tremor, stiffness, and slowness
• Patients requiring better symptom stability in advanced Parkinson’s disease

Mechanism of Action

Safinamide Mesylate works through dual action in the brain:

• Selective MAO-B inhibition: Increases dopamine levels by preventing its breakdown, thereby improving motor function.
• Glutamate modulation: Reduces excessive glutamate release, which may help improve neuronal stability and motor symptoms.

This combined mechanism helps enhance dopamine activity and improve movement control in Parkinson’s disease patients.

Dosage & Administration

• The dose is determined by a physician based on patient condition and response to levodopa therapy.
• Usually taken once daily at the same time each day.
• Can be taken with or without food.
• Do not change or stop medication without medical supervision.
• May be used as part of combination therapy with other Parkinson’s disease medicines.

Precautions

• Use with caution in patients with liver impairment
• Not recommended in severe hepatic dysfunction
• Monitor for signs of serotonin syndrome when used with antidepressants
• May increase dyskinesia when used with levodopa
• Patients with psychiatric history should be closely monitored
• Avoid abrupt discontinuation without medical advice

Side Effects

Possible side effects include:

• Dyskinesia (involuntary movements)
• Nausea
• Insomnia
• Dizziness
• Headache
• Orthostatic hypotension
• Hallucinations or confusion in sensitive individuals

Seek immediate medical attention if severe psychiatric symptoms, chest pain, or unusual muscle rigidity occur.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Safina Tablet may interact with:

• Antidepressants (SSRIs, SNRIs, tricyclics)
• Other MAO inhibitors
• Opioid analgesics such as tramadol
• Dopaminergic drugs used in Parkinson’s therapy

A full medication history should be reviewed before starting treatment.

Storage

• Store below 30°C in a cool, dry place
• Protect from moisture and sunlight
• Keep out of reach of children.