Terbinafine Hydrochloride belongs to the allylamine class of antifungal agents. It acts by selectively inhibiting the enzyme squalene epoxidase, a key enzyme in the fungal sterol biosynthesis pathway. This inhibition results in a deficiency of ergosterol, an essential component of the fungal cell membrane, and an accumulation of squalene within the fungal cell. The combined effect leads to disruption of cell membrane integrity and fungal cell death.
Terbinafine exhibits fungicidal activity against dermatophytes and fungistatic activity against certain yeasts and molds, making it highly effective for systemic treatment of fungal infections.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Terbex Tablet 250 mg is indicated for the treatment of:

• Onychomycosis (fungal infections of fingernails and toenails)

• Tinea corporis (ringworm)

• Tinea cruris (jock itch)

• Tinea pedis (athlete’s foot)

• Tinea capitis (scalp fungal infections), as advised by a physician

Dosage and Administration

• Dosage should be determined by a physician based on the type and severity of infection

• The usual adult dose is 250 mg once daily

• Tablets may be taken with or without food

• Duration of treatment varies depending on the site of infection, particularly for nail infections which may require prolonged therapy

• Patients should complete the full course of treatment for optimal results

Contraindications

• Hypersensitivity to terbinafine or any component of the formulation

• Chronic or active liver disease

Warnings and Precautions

• Liver function tests should be performed before initiating therapy and periodically during treatment

• Use with caution in patients with renal impairment

• Discontinue treatment if signs of liver dysfunction occur

• Not recommended for patients with severe renal or hepatic impairment without medical supervision

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Commonly reported side effects include:

• Gastrointestinal disturbances such as nausea, diarrhea, or abdominal pain

• Headache

• Skin rash or itching

• Taste disturbance

Rare but serious adverse effects may include hepatotoxicity and severe skin reactions.

Drug Interactions

• Terbinafine may interact with drugs metabolized by the cytochrome P450 system

• Caution is advised when used with antidepressants, beta-blockers, and certain antiarrhythmic agents

Use in Pregnancy and Lactation

• Use during pregnancy only if the potential benefit justifies the possible risk

• Breastfeeding is not recommended during therapy as terbinafine is excreted in breast milk

Storage Conditions

• Store below 30°C in a cool and dry place

• Protect from moisture and light

• Keep out of reach of children

Presentation

Terbex Tablet 250 mg is available in blister packs designed for stability, safety, and convenient oral administration.