Tenobis-A Tablet 2.5 mg+5 mg is a fixed-dose combination medicine containing Bisoprolol Fumarate 2.5 mg and Amlodipine Besilate 5 mg. It is indicated for the effective management of hypertension (high blood pressure) and may also be used in patients with chronic stable angina who require combination therapy for optimal cardiovascular control.

This dual-action formulation combines a cardioselective beta-blocker with a calcium channel blocker to provide comprehensive blood pressure reduction. By targeting two different pathways involved in blood pressure regulation, Tenobis-A helps achieve better control while reducing the risk of cardiovascular complications such as heart attack and stroke.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Bisoprolol Fumarate 2.5 mg

• Amlodipine Besilate 5 mg

Mechanism of Action

Bisoprolol is a selective beta-1 adrenergic receptor blocker that primarily acts on the heart. It reduces heart rate and myocardial contractility, thereby lowering cardiac output and blood pressure. This action decreases the heart’s oxygen demand and supports long-term cardiac protection.

Amlodipine is a calcium channel blocker that relaxes and widens blood vessels by preventing calcium from entering vascular smooth muscle cells. This leads to reduced peripheral resistance and improved blood flow.

Together, these two agents provide complementary effects—one acting on the heart and the other on blood vessels—resulting in effective and sustained blood pressure control.

Indications

Tenobis-A Tablet 2.5 mg+5 mg is indicated for:

• Treatment of essential hypertension

• Patients not adequately controlled with single-agent therapy

• Management of hypertension associated with stable angina

• Long-term cardiovascular risk reduction

It may be prescribed as part of a comprehensive treatment plan under medical supervision.

Dosage and Administration

• The usual recommended dose is one tablet once daily or as directed by a physician.

• It can be taken with or without food.

• Swallow the tablet whole with water.

• Take at the same time each day for consistent therapeutic effect.

Do not discontinue abruptly without consulting a healthcare provider.

Benefits

• Dual mechanism for enhanced blood pressure control

• Reduces heart rate and vascular resistance

• Helps prevent angina episodes

• Lowers risk of heart attack and stroke

• Convenient once-daily dosing for improved compliance

Precautions

• Monitor blood pressure and heart rate regularly.

• Use cautiously in patients with asthma, diabetes, or heart conduction disorders.

• Amlodipine may cause peripheral edema in some patients.

• Not recommended in severe bradycardia, cardiogenic shock, or advanced heart block without specialist supervision.

• Use during pregnancy only if clearly advised by a physician.

Regular follow-up visits are essential during treatment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Dizziness

• Fatigue

• Slow heart rate

• Ankle swelling

• Headache

• Mild gastrointestinal discomfort

Most side effects are mild and temporary. Seek immediate medical attention if severe hypotension, breathing difficulty, or worsening cardiac symptoms occur.

Storage

• Store below 30°C

• Keep in a dry place away from moisture

• Protect from direct sunlight

• Keep out of reach of children

Tenobis-A Tablet 2.5 mg+5 mg offers a balanced and effective combination therapy for patients requiring comprehensive blood pressure and cardiovascular management under proper medical supervision.