Angiotensin II is a key component of the renin-angiotensin-aldosterone (RAA) system and is responsible for vasoconstriction, aldosterone release, cardiac stimulation, and renal sodium reabsorption, all of which contribute to elevated blood pressure. Telmisartan selectively blocks the binding of angiotensin II to the AT1 receptor present in vascular smooth muscle and the adrenal gland.
By inhibiting these effects, Telma 40 mg promotes vasodilation, reduces aldosterone secretion, decreases peripheral vascular resistance, and lowers blood pressure. Telmisartan has a high affinity for the AT1 receptor, more than 3,000-fold greater than for the AT2 receptor. Since it does not inhibit angiotensin-converting enzyme (ACE), it does not interfere with bradykinin metabolism, reducing the likelihood of ACE-inhibitor-related cough. The antihypertensive effect is sustained over 24 hours with once-daily dosing.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Telma Tablet 40 mg is indicated for:

• Treatment of essential hypertension in adults

• Reduction of cardiovascular morbidity in adults with atherothrombotic cardiovascular disease, including a history of coronary heart disease, stroke, or peripheral arterial disease

• Cardiovascular risk reduction in adults with type 2 diabetes mellitus and documented target organ damage

Dosage and Administration

• The usual starting dose is 40 mg once daily

• Blood pressure response is dose-related within the range of 20–80 mg

• Most of the antihypertensive effect is seen within 2 weeks, with maximal effect by 4 weeks

• Tablets may be taken with or without food

• Dosage should be individualized based on patient response

• No initial dose adjustment is required for elderly patients or those with renal impairment, including patients on hemodialysis, although close monitoring is advised

Drug Interactions

• Concomitant use with NSAIDs may reduce antihypertensive effect and increase the risk of renal impairment

• Use with aliskiren should be avoided in patients with diabetes

• Caution is advised when used with other agents affecting the RAA system

Contraindications

• Hypersensitivity to telmisartan or any component of the formulation

Side Effects

In hypertensive patients, commonly reported side effects include:

• Sinus pain and congestion

• Back pain

• Diarrhea

In cardiovascular risk reduction patients, side effects may include:

• Intermittent claudication

• Skin ulcer

Most adverse effects are mild and transient.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pregnancy and Lactation

• Telma 40 mg is categorized as Pregnancy Category C during the first trimester and Category D during the second and third trimesters

• It should be discontinued as soon as pregnancy is detected

• Use during breastfeeding is not recommended due to potential risk to the nursing infant

Precautions and Warnings

• Avoid fetal and neonatal exposure

• Use with caution in patients with hepatic or renal impairment

• Hypotension may occur, especially in volume-depleted patients

• Avoid concomitant use of ACE inhibitors and ARBs

Storage Conditions

• Store below 30°C

• Protect from light and high humidity

• Keep out of reach of children

Presentation

Telma Tablet 40 mg is supplied in blister packs for safe storage and convenient daily use.