Soforal-LP Tablet 90 mg+400 mg is a fixed-dose combination antiviral medication containing Ledipasvir and Sofosbuvir. It is used for the treatment of chronic Hepatitis C virus (HCV) infection. This combination therapy is highly effective and is commonly prescribed for specific HCV genotypes to achieve sustained virologic response (SVR), which can result in a functional cure of the infection in most patients.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Ledipasvir 90 mg
• Sofosbuvir 400 mg

Mechanism of Action

Soforal-LP Tablet works through dual inhibition of Hepatitis C virus replication:

• Ledipasvir: Inhibits the NS5A protein, which is essential for viral RNA replication and assembly.
• Sofosbuvir: A nucleotide analog inhibitor that targets the NS5B RNA-dependent RNA polymerase enzyme, blocking viral replication.

Together, these agents significantly reduce viral load and help eliminate the virus from the body when used as part of a complete treatment regimen.

Indications

Soforal-LP Tablet is indicated for:

• Treatment of chronic Hepatitis C virus (HCV) infection (specific genotypes as determined by physician)
• Patients with or without compensated liver disease
• Use in combination or as per approved treatment protocols depending on clinical condition

Dosage and Administration

• The usual recommended dose is one tablet once daily.
• Can be taken with or without food.
• Must be used exactly as prescribed by a healthcare professional.
• Treatment duration typically ranges from 8 to 12 weeks, depending on patient condition and viral genotype.
• Adherence to the full course is essential for successful treatment outcome.

Benefits

• High cure rates for Hepatitis C infection
• Once-daily oral dosing improves compliance
• Shorter treatment duration compared to older therapies
• Well-tolerated with manageable side effects
• Effective in reducing liver damage progression associated with HCV

Side Effects

Common side effects may include:

• Fatigue
• Headache
• Nausea
• Diarrhea
• Insomnia

Rare but serious side effects may include severe bradycardia (especially with certain heart medications), allergic reactions, or worsening liver function in advanced disease.

Precautions and Warnings

• Not recommended for use without proper medical diagnosis of HCV genotype.
• Use with caution in patients with severe liver impairment.
• Regular monitoring of liver function is required during treatment.
• Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.
• Caution in patients taking heart rhythm medications such as amiodarone.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Soforal-LP Tablet may interact with:

• Amiodarone (risk of severe bradycardia)
• Anticonvulsants (may reduce effectiveness)
• Rifampin and other strong enzyme inducers
• Certain antiretroviral medications

Always inform your healthcare provider about all current medications.

Storage

• Store below 30°C in a cool, dry place
• Protect from moisture and direct sunlight
• Keep out of reach of children.