Sodival CR Tablet 300 mg contains Sodium Valproate, a broad-spectrum anticonvulsant and mood-stabilizing agent used in the management of epilepsy, bipolar disorder, and seizure-related conditions. The controlled-release (CR) formulation ensures a gradual and consistent release of the active ingredient, providing steady therapeutic levels and reducing the frequency of dosing.

This tablet is particularly beneficial for patients requiring long-term seizure control or mood stabilization, offering enhanced compliance and minimized side effects due to its controlled-release design.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Sodium Valproate 300 mg per controlled-release tablet

Mechanism of Action

• Sodium Valproate increases gamma-aminobutyric acid (GABA) levels in the central nervous system, an inhibitory neurotransmitter that suppresses abnormal electrical activity in the brain.
• Helps prevent the spread of seizures and stabilizes neuronal excitability.
• Modulates neurotransmitter systems involved in mood regulation, helping to manage mania and mood swings in bipolar disorder.
• The CR formulation maintains stable plasma concentration, minimizing peaks and troughs that can trigger side effects.

Indications

Sodival CR Tablet 300 mg is indicated for:

• Epilepsy: generalized, partial, and mixed seizure types
• Bipolar disorder: treatment and prevention of manic and mixed episodes
• Migraine prophylaxis (off-label use in select patients)
• Other neurological disorders benefiting from GABAergic modulation

Dosage & Administration

• Take exactly as prescribed by a physician
• Swallow the tablet whole with water, preferably after a meal to reduce gastrointestinal irritation
• Adults typically start with 300–600 mg once or twice daily, adjusted based on clinical response and serum levels
• Dose adjustments are required for children, elderly, or patients with liver impairment
• Do not crush or chew the tablet to maintain controlled-release properties

Benefits

• Effective in reducing seizure frequency and severity
• Stabilizes mood in bipolar disorder
• Controlled-release formulation allows consistent therapeutic effect
• Reduces dosing frequency, improving patient compliance
• Supports long-term neurological and psychiatric health

Possible Side Effects

Common side effects:

• Nausea, vomiting, or mild gastrointestinal discomfort
• Drowsiness, dizziness, or tremors
• Weight gain or increased appetite
• Temporary hair thinning

Serious but rare side effects:

• Liver toxicity (hepatitis, elevated liver enzymes)
• Pancreatitis
• Severe allergic reactions (rash, swelling, difficulty breathing)
• Blood disorders such as thrombocytopenia or leukopenia

Precautions & Warnings

• Regular liver function tests and blood counts are recommended
• Avoid in patients with known liver disease or urea cycle disorders
• Not recommended during pregnancy, unless strictly necessary, due to risk of fetal malformations
• Do not abruptly discontinue to avoid seizure recurrence
• Inform your physician about all other medications to prevent drug interactions

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store at 20–25°C in a dry, cool place
• Keep the tablet in its original container, away from moisture and light
• Keep out of reach of children

Conclusion

Sodival CR Tablet 300 mg (Sodium Valproate) is a controlled-release anticonvulsant and mood stabilizer that provides effective management of epilepsy and bipolar disorder. Its formulation ensures consistent blood levels, improved compliance, and reduced side effects, making it a reliable option for long-term therapy.