Seraflo Inhalation Capsule 50 mcg+250 mcg is a high-potency combination of Salmeterol, a long-acting bronchodilator, and Fluticasone Propionate, an inhaled corticosteroid. Designed for use with a dry powder inhaler (DPI), this formulation provides effective maintenance therapy for asthma and chronic obstructive pulmonary disease (COPD), offering both long-lasting bronchodilation and anti-inflammatory action.

Salmeterol works by relaxing the smooth muscles in the airways, providing extended relief from bronchospasm, while Fluticasone Propionate reduces airway inflammation, swelling, and mucus production. Together, they help patients manage chronic respiratory symptoms, prevent exacerbations, and maintain optimal lung function. This higher-dose formulation is particularly suitable for patients whose asthma or COPD is not adequately controlled with lower doses of corticosteroids.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Salmeterol 50 mcg per inhalation

• Fluticasone Propionate 250 mcg per inhalation

Mechanism of Action

Seraflo Inhalation Capsule combines two complementary mechanisms:

1. Salmeterol (Long-Acting β2-Adrenergic Agonist):

   • Stimulates β2-adrenergic receptors in bronchial smooth muscles

   • Causes relaxation of airway muscles, resulting in prolonged bronchodilation

   • Reduces wheezing, shortness of breath, and bronchospasm

2. Fluticasone Propionate (Inhaled Corticosteroid):

   • Suppresses airway inflammation by inhibiting inflammatory mediators

   • Reduces airway edema and mucus production

   • Prevents airway remodeling and decreases the frequency of exacerbations

The combination provides both immediate relief from bronchospasm and long-term anti-inflammatory protection, addressing both symptoms and the underlying pathology of chronic respiratory disease.

Indications

Seraflo Inhalation Capsule 50 mcg+250 mcg is indicated for:

• Maintenance therapy of asthma in adults and adolescents not adequately controlled by corticosteroid monotherapy

• Long-term management of COPD with persistent symptoms

• Prevention of asthma and COPD exacerbations

• Patients requiring higher-dose anti-inflammatory therapy alongside bronchodilation

It is not intended for acute symptom relief; a short-acting bronchodilator should be used in emergencies.

Dosage and Administration

• The typical dosage is one inhalation twice daily (morning and evening) using a dry powder inhaler.

• Insert the capsule into the DPI and pierce it as per the device instructions.

• Inhale the powder deeply, hold the breath for 10 seconds, then exhale slowly.

• Rinse the mouth with water after each use to minimize the risk of oral thrush.

Consistent use is critical for maintaining symptom control and preventing exacerbations.

Benefits

• Provides long-lasting bronchodilation and potent anti-inflammatory action

• Reduces airway inflammation, wheezing, and shortness of breath

• Decreases the frequency and severity of asthma and COPD attacks

• Convenient inhalation capsule for targeted delivery to the lungs

• Improves lung function and overall quality of life

Precautions

• Not for acute asthma attacks

• Use cautiously in patients with heart disease, hypertension, diabetes, or thyroid disorders

• Monitor for potential corticosteroid-related systemic effects with long-term use

• Consult a physician before use during pregnancy or breastfeeding

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects:

• Oral thrush or sore throat

• Hoarseness or throat irritation

• Tremors, palpitations, or mild dizziness

• Headache

Rare but serious side effects:

• Severe allergic reactions

• Paradoxical bronchospasm

• Cardiovascular effects such as arrhythmias or hypertension

Storage

Store below 30°C in a dry, cool place, away from sunlight and moisture. Keep capsules in the blister pack until use, and keep out of reach of children.

Seraflo Inhalation Capsule 50 mcg+250 mcg provides high-potency, long-term management of asthma and COPD, combining Salmeterol and Fluticasone Propionate to improve lung function, reduce exacerbations, and enhance overall respiratory health.