Savesto Tablet 24 mg + 26 mg contains a combination of Sacubitril and Valsartan, used for the management of chronic heart failure. It is designed to improve heart function, reduce symptoms, and lower the risk of hospitalization and cardiovascular death in patients with reduced ejection fraction heart failure (HFrEF). This lower-strength formulation is often used as an initial or adjusted dose based on patient tolerance.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Sacubitril 24 mg
• Valsartan 26 mg

Indications

Savesto Tablet is indicated for:

• Chronic heart failure with reduced ejection fraction (HFrEF)
• Symptomatic heart failure management in clinically stable patients
• Reduction of cardiovascular mortality and heart failure-related hospitalizations

Mechanism of Action

Savesto works through a dual mechanism:

• Sacubitril inhibits neprilysin, increasing beneficial natriuretic peptides that help reduce fluid overload, promote vasodilation, and decrease cardiac stress
• Valsartan blocks angiotensin II receptors, reducing vasoconstriction, sodium retention, and blood pressure

Together, these effects reduce strain on the heart and improve overall cardiac performance.

Dosage and Administration

• The usual dose is one tablet twice daily or as directed by a physician
• Can be taken with or without food
• Swallow the tablet whole with water
• Dose is usually started low and gradually adjusted based on patient response
• Do not stop the medication without medical advice

Benefits

• Improves heart pumping efficiency
• Reduces risk of hospitalization due to heart failure
• Lowers cardiovascular mortality risk
• Helps control symptoms such as shortness of breath and fatigue
• Improves quality of life in heart failure patients

Possible Side Effects

Common side effects may include:

• Dizziness or low blood pressure
• Elevated potassium levels
• Fatigue
• Cough
• Nausea

Serious side effects:

• Angioedema (swelling of face, lips, or throat)
• Severe kidney impairment
• Dangerous electrolyte imbalance

Seek immediate medical help if severe symptoms occur.

Precautions and Warnings

• Not recommended during pregnancy due to risk of fetal harm
• Use cautiously in patients with kidney or liver disease
• Regular monitoring of blood pressure, kidney function, and potassium levels is required
• Avoid concurrent use with ACE inhibitors (requires proper washout period)
• May cause dizziness; caution during driving or operating machinery

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Savesto Tablet may interact with:

• ACE inhibitors
• Potassium supplements and potassium-sparing diuretics
• NSAIDs (e.g., diclofenac, ibuprofen)
• Other antihypertensive medications

Always inform your doctor about all medicines you are taking.

Storage

• Store below 30°C in a cool, dry place
• Protect from moisture and direct sunlight
• Keep out of reach of children.