Pradox Injection 1000 mg/ml contains Pralidoxime Chloride, an antidote used in the treatment of organophosphate poisoning, including exposure to certain pesticides and nerve agents. It works by reactivating cholinesterase enzymes that have been inhibited by toxic compounds. Pradox is commonly administered in emergency and critical care settings alongside atropine to reverse life-threatening symptoms of poisoning.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Pralidoxime Chloride 1000 mg/ml

Mechanism of Action

Pralidoxime acts by restoring the activity of acetylcholinesterase, an enzyme inhibited by organophosphates. Its actions include:

• Reactivating inhibited cholinesterase enzymes
• Reducing the accumulation of acetylcholine at nerve endings
• Reversing neuromuscular blockade and respiratory depression
• Improving muscle strength and breathing

This mechanism helps counteract the toxic effects of organophosphate poisoning.

Indications

Pradox Injection is indicated for:

• Organophosphate pesticide poisoning
• Nerve agent poisoning
• Poisoning due to cholinesterase inhibitors
• As an adjunct to atropine therapy in acute toxicity cases

Dosage and Administration

• Administered intravenously or intramuscularly under medical supervision
• Dosage depends on the severity of poisoning and patient condition
• Often given in combination with atropine for optimal effect
• Repeated doses may be required based on clinical response

Benefits

• Effective antidote for organophosphate poisoning
• Restores neuromuscular function
• Improves respiratory function
• Essential in emergency and life-saving treatment

Side Effects

Possible side effects include:

• Dizziness or headache
• Increased heart rate (tachycardia)
• Blurred vision
• Nausea
• Injection site reactions

Serious adverse reactions are rare but require immediate medical attention.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Use with caution in patients with kidney impairment
• Monitor vital signs and respiratory function closely
• Should be administered by trained healthcare professionals
• Not effective for all types of poisoning (e.g., carbamate poisoning may respond differently)

Storage

• Store at controlled room temperature
• Protect from light
• Do not freeze
• Keep out of reach of children.