Polycef Injection 500 mg/vial contains Cephradine, a first-generation cephalosporin antibiotic used for the treatment of moderate to severe bacterial infections. Cephradine works by inhibiting bacterial cell wall synthesis, leading to the destruction of susceptible bacteria. It is effective against gram-positive bacteria and selected gram-negative bacteria, making it suitable for respiratory tract infections, skin and soft tissue infections, urinary tract infections, bone infections, and septicemia.

The injectable form allows for rapid administration and systemic absorption, providing immediate therapeutic levels in patients who require intravenous or intramuscular therapy, such as hospitalized patients or those unable to take oral antibiotics. Polycef Injection 500 mg is ideal for acute infections, serious bacterial infections, or when oral administration is not feasible.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Features

• Contains Cephradine 500 mg per vial

• First-generation cephalosporin antibiotic

• Effective for moderate to severe bacterial infections

• Injectable form for IV or IM administration

• Rapid systemic absorption for immediate therapeutic effect

• Suitable for respiratory, urinary, skin, bone, and septic infections

Indications

Polycef Injection 500 mg/vial is indicated for:

• Respiratory tract infections: Pneumonia, bronchitis, tonsillitis, and pharyngitis caused by susceptible bacteria

• Skin and soft tissue infections: Cellulitis, abscesses, wound infections

• Urinary tract infections: Pyelonephritis, cystitis, urethritis

• Bone and joint infections: Osteomyelitis, septic arthritis

• Septicemia and other systemic bacterial infections

• Prophylaxis: In certain surgical procedures to prevent postoperative infections

Mechanism of Action

Cephradine acts by:

• Binding to penicillin-binding proteins (PBPs) on the bacterial cell wall

• Inhibiting cell wall synthesis, causing bacterial lysis and death

• Targeting actively dividing bacteria, effectively controlling bacterial growth

This mechanism ensures rapid bacterial eradication and helps prevent the spread of infection.

Dosage and Administration

• Adult dose: Typically 500 mg to 1 g every 6–12 hours, depending on infection severity and site

• Pediatric dose: Calculated based on body weight, usually 25–50 mg/kg/day divided into 3–4 doses

• Administer via intravenous (IV) or intramuscular (IM) injection as prescribed

• IV infusion should be given over 10–30 minutes for optimal effect

• Ensure proper reconstitution with sterile water or compatible diluent before use

• Therapy duration depends on infection severity and clinical response

Possible Side Effects

Common side effects:

• Local reactions at injection site: pain, redness, or swelling

• Nausea, vomiting, or diarrhea

• Rash or mild allergic reactions

Serious but rare side effects:

• Severe allergic reactions, including anaphylaxis

• Clostridium difficile-associated diarrhea

• Blood disorders such as leukopenia or thrombocytopenia

• Liver or kidney function abnormalities

Patients should seek immediate medical attention if they experience severe allergic reactions, persistent diarrhea, or unusual bleeding.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Use only under medical supervision

• Inform the doctor about allergies, especially to penicillin or cephalosporins

• Adjust dose in patients with kidney impairment

• Monitor for signs of superinfection during prolonged therapy

• Pregnant or breastfeeding patients should consult a physician before use

Storage Instructions

• Store in a cool, dry place below 25°C

• Protect from light and moisture

• Keep vials in the original packaging until use

• Keep out of reach of children.