Pirfedone Tablet 534 mg contains Pirfenidone, a potent antifibrotic and anti-inflammatory medication specifically indicated for the treatment of idiopathic pulmonary fibrosis (IPF). IPF is a progressive lung disease marked by excessive scarring of lung tissue, which results in reduced oxygen exchange, chronic breathlessness, fatigue, and decreased overall quality of life.

Pirfenidone works by modulating pathways that drive fibrosis and inflammation in the lungs. It inhibits the activity of transforming growth factor-beta (TGF-β) and other fibrotic mediators, reducing collagen deposition and fibroblast proliferation. Additionally, Pirfenidone suppresses inflammatory cytokines such as TNF-alpha and interleukin-1, which play a key role in tissue damage. By targeting both fibrotic and inflammatory processes, Pirfedone helps slow disease progression, preserve lung function, and improve patient outcomes.

The 534 mg tablet offers a higher-dose formulation for adults, facilitating effective titration to achieve the recommended daily dose while maintaining convenience for oral administration. Regular dosing is critical for sustaining therapeutic levels and ensuring maximal antifibrotic effect.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Features

• Contains Pirfenidone 534 mg per tablet

• Antifibrotic and anti-inflammatory action for idiopathic pulmonary fibrosis

• Slows lung scarring and preserves lung function

• Oral tablet for convenient long-term therapy

• Helps improve exercise tolerance and quality of life

• Suitable for titrated dosing in adult patients under specialist supervision

Indications

Pirfedone Tablet 534 mg is indicated for:

• Idiopathic Pulmonary Fibrosis (IPF): To slow disease progression and preserve lung function

• Fibrosis-related respiratory conditions: Prescribed under specialist guidance

• Supportive therapy: Maintains patient quality of life, exercise tolerance, and lung capacity

It should always be used under the care of a pulmonologist or specialist physician, with monitoring of lung function and general health.

Mechanism of Action

Pirfenidone exerts its effect through a dual antifibrotic and anti-inflammatory mechanism:

• Inhibits TGF-β and collagen synthesis, reducing fibroblast activity and excessive scarring

• Suppresses inflammatory cytokines such as TNF-alpha and IL-1, preventing further tissue damage

• Slows the progression of pulmonary fibrosis, helping preserve lung elasticity and respiratory function

• Reduces fibroblast proliferation and extracellular matrix deposition, targeting the root cause of disease

This combined action addresses both the fibrotic and inflammatory components of IPF.

Dosage and Administration

• Pirfedone is usually titrated gradually to reach the recommended therapeutic dose

• Tablets are taken orally three times daily with food to minimize gastrointestinal discomfort

• Dose adjustments may be required in patients with liver or kidney impairment

• Regular monitoring of liver function, kidney function, and lung status is essential

• Adherence to prescribed dosing is crucial for effectiveness

Possible Side Effects

Common side effects:

• Nausea, vomiting, or diarrhea

• Fatigue and dizziness

• Loss of appetite

• Skin rash or photosensitivity

• Mild gastrointestinal discomfort

Serious but rare side effects:

• Liver function abnormalities

• Severe skin reactions or photosensitivity

• Allergic reactions

• Persistent gastrointestinal issues requiring medical attention

Patients should report any severe or unusual symptoms immediately to their physician.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Use only under specialist supervision

• Avoid excessive sunlight exposure; use protective measures to prevent photosensitivity

• Regular liver and kidney function monitoring is recommended

• Inform your doctor about all concurrent medications to prevent drug interactions

• Not recommended during pregnancy or breastfeeding without medical supervision

Storage Instructions

• Store in a cool, dry place below 25°C

• Protect from light and moisture

• Keep tablets in the original container, tightly closed

• Keep out of reach of children.