Dinovo Tablet is a fixed-dose combination of Naproxen Sodium (500 mg) and Esomeprazole Magnesium (20 mg), designed to provide effective relief from pain and inflammation while reducing the risk of gastrointestinal complications associated with long-term nonsteroidal anti-inflammatory drug (NSAID) therapy. This dual-action formulation makes Dinovo Tablet particularly suitable for patients who require sustained pain management and are at risk of gastric irritation or ulcers.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Naproxen Sodium 500 mg

• Esomeprazole Magnesium 20 mg

Therapeutic Class

Nonsteroidal Anti-inflammatory Drug (NSAID)
Proton Pump Inhibitor (PPI)

Pharmacology

Naproxen Sodium is an NSAID that works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins responsible for pain, inflammation, swelling, and fever. It provides potent and long-lasting analgesic and anti-inflammatory effects, making it effective in a wide range of musculoskeletal and inflammatory conditions.

Esomeprazole Magnesium is a proton pump inhibitor that suppresses gastric acid secretion by inhibiting the H⁺/K⁺-ATPase enzyme system in the gastric parietal cells. By reducing stomach acid production, esomeprazole helps protect the gastric mucosa and lowers the risk of NSAID-induced gastric ulcers, erosions, and dyspepsia.

The combination ensures effective pain control while maintaining gastrointestinal safety, especially during prolonged therapy.

Indications

Dinovo Tablet is indicated for the treatment of:

• Osteoarthritis

• Rheumatoid arthritis

• Ankylosing spondylitis

• Chronic musculoskeletal pain

• Acute pain and inflammatory conditions

• Patients requiring NSAID therapy with a risk of gastric ulceration

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

• The usual recommended dose is one tablet once daily or as prescribed by a physician.

• The tablet should be swallowed whole with water and should not be crushed or chewed.

• It is preferably taken before meals to ensure optimal acid suppression.

Dosage and duration of treatment should be individualized based on patient response and clinical condition.

Contraindications

Dinovo Tablet is contraindicated in patients with:

• Known hypersensitivity to naproxen, esomeprazole, or other NSAIDs

• Active gastrointestinal bleeding or peptic ulcer disease

• Severe hepatic or renal impairment

• History of NSAID-induced asthma

• Pregnancy, especially during the third trimester

Precautions and Warnings

• Prolonged use of NSAIDs may increase the risk of cardiovascular events; use the lowest effective dose for the shortest duration.

• Caution is advised in elderly patients and those with a history of gastrointestinal disorders.

• Renal and liver function should be monitored during long-term therapy.

• Avoid concurrent use with other NSAIDs unless advised by a physician.

Side Effects

Possible side effects include:

• Nausea, abdominal pain, or dyspepsia

• Headache or dizziness

• Diarrhea or constipation

• Increased blood pressure with long-term use

Most side effects are mild and resolve with continued treatment or dose adjustment.

Use in Special Populations

• Pregnancy: Not recommended, particularly in late pregnancy.

• Lactation: Use with caution and under medical advice.

• Elderly: Close monitoring is recommended due to increased risk of adverse effects.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.