Periset Injection 8 mg/4 ml contains Ondansetron, a potent selective 5-HT3 receptor antagonist used to prevent and treat nausea and vomiting associated with chemotherapy, radiotherapy, and surgical procedures. Ondansetron works by blocking serotonin receptors (5-HT3) in the central nervous system and gastrointestinal tract, which are primarily responsible for initiating the vomiting reflex.

This injection formulation is intended for intravenous administration, providing rapid onset of action and reliable control of both acute and delayed episodes of nausea and vomiting. Periset Injection is widely used in hospital and clinical settings for patients who need immediate and effective antiemetic therapy, ensuring better patient comfort and adherence to treatment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Benefits

• Prevents chemotherapy-induced nausea and vomiting (CINV)

• Controls radiotherapy-induced nausea and vomiting (RINV)

• Reduces postoperative nausea and vomiting (PONV)

• Rapid onset of action due to intravenous administration

• Effective in both acute (0–24 hours) and delayed (24–120 hours) phases

• Improves patient comfort and treatment adherence in clinical settings

Mechanism of Action

Ondansetron, the active ingredient in Periset Injection, acts as a selective 5-HT3 receptor antagonist:

1. Serotonin Receptor Blockade:

   • Chemotherapy, radiotherapy, or surgical stress triggers the release of serotonin from enterochromaffin cells in the gut.

   • Serotonin binds to 5-HT3 receptors on vagal nerve terminals, activating the vomiting center in the brain.

   • Ondansetron blocks these receptors, preventing transmission of nausea and vomiting signals.

2. Peripheral and Central Action:

   • Works on 5-HT3 receptors in both the gastrointestinal tract and central nervous system, providing comprehensive antiemetic protection.

3. Rapid Onset and Long Duration:

   • Intravenous administration ensures immediate therapeutic levels, offering effective relief from acute nausea and vomiting.

   • Extended half-life supports prolonged antiemetic coverage, reducing the need for repeated doses.

Indications

Periset Injection 8 mg/4 ml is indicated for:

• Prevention and treatment of chemotherapy-induced nausea and vomiting (CINV)

• Prevention of radiotherapy-induced nausea and vomiting (RINV)

• Prevention and management of postoperative nausea and vomiting (PONV)

• Suitable for adult patients requiring rapid and reliable antiemetic therapy

Dosage and Administration

• Adults: 8 mg administered intravenously slowly over 2–5 minutes approximately 30 minutes before chemotherapy or surgery.

• Pediatrics: Use only under medical supervision, with dose adjusted according to body weight and clinical indication.

• Do not exceed recommended dose; repeat doses should be as advised by the physician.

• Ensure proper IV line flushing after administration to prevent local irritation.

Precautions and Warnings

• Use with caution in patients with cardiac arrhythmias or prolonged QT interval.

• Avoid in patients with hypersensitivity to Ondansetron or other 5-HT3 antagonists.

• Monitor patients taking other drugs that may prolong the QT interval.

• Pregnant and breastfeeding women should use only under medical supervision.

• Monitor liver function in patients with hepatic impairment, as dose adjustment may be necessary.

Possible Side Effects

Periset Injection is generally well-tolerated. Common side effects include:

• Headache

• Constipation or diarrhea

• Dizziness or fatigue

• Rare allergic reactions, arrhythmias, or severe hypersensitivity

Seek immediate medical attention if severe reactions such as rash, swelling, or difficulty breathing occur.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

Store at 2–8°C, protected from light. Do not freeze. Keep out of reach of children.

Periset Injection 8 mg/4 ml provides fast, effective, and long-lasting prevention of nausea and vomiting, making it a critical option for patients undergoing chemotherapy, radiotherapy, or surgery.