Perinem Injection 500 mg/vial contains Doripenem, a broad-spectrum carbapenem antibiotic used for the treatment of serious bacterial infections. Doripenem is highly effective against a wide range of Gram-positive and Gram-negative bacteria, including multidrug-resistant strains. It works by inhibiting bacterial cell wall synthesis, leading to cell death, making it a vital option for severe infections where other antibiotics may be less effective.

Perinem Injection is intended for intravenous administration in hospital or clinical settings. Its formulation ensures rapid delivery into the bloodstream, allowing effective control of systemic infections. It is commonly prescribed for adults and, under specialist supervision, in pediatric populations for life-threatening infections.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Mechanism of Action

Doripenem binds to penicillin-binding proteins (PBPs) in bacterial cell walls, disrupting the final step of peptidoglycan synthesis. This inhibition weakens the bacterial cell wall, leading to osmotic instability and bacterial cell death. Doripenem is highly resistant to most beta-lactamases, making it effective against bacteria that have developed resistance to other beta-lactam antibiotics.

Indications

Perinem Injection 500 mg/vial is indicated for the treatment of:

• Complicated intra-abdominal infections

• Complicated urinary tract infections, including pyelonephritis

• Hospital-acquired and ventilator-associated pneumonia

• Septicemia and systemic bacterial infections

• Other severe infections caused by susceptible Gram-positive and Gram-negative bacteria

Therapy should be guided by clinical assessment, microbiological testing, and sensitivity of the infecting organism.

Dosage and Administration

• The usual adult dose is 500 mg intravenously every 8 hours, administered over 1 hour.

• Dosage may vary depending on infection severity, renal function, and patient-specific factors.

• Reconstitution with appropriate diluents is required before intravenous administration.

• Complete the full course of therapy, even if symptoms improve, to prevent bacterial resistance and relapse.

• Monitor renal function in patients with impaired kidney function, as dose adjustment may be necessary.

Benefits of Perinem Injection

• Broad-spectrum activity against multidrug-resistant bacteria

• Effective for severe and complicated infections

• Rapid intravenous delivery ensures immediate systemic action

• Reduces bacterial load and prevents the spread of infection

• Clinically proven efficacy in hospital and intensive care settings

Possible Side Effects

Common side effects include:

• Nausea and vomiting

• Diarrhea

• Injection site reactions such as pain or redness

• Headache

• Rash or mild hypersensitivity reactions

Serious but rare side effects may include:

• Severe allergic reactions or anaphylaxis

• Seizures in patients with pre-existing CNS disorders

• Clostridium difficile-associated diarrhea

• Elevated liver enzymes or kidney dysfunction

Patients should be monitored for any unusual symptoms, and therapy should be adjusted as needed.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Avoid use in patients with known hypersensitivity to carbapenems or beta-lactam antibiotics

• Use cautiously in patients with a history of seizures or CNS disorders

• Monitor renal function during prolonged therapy

• Administer only under professional supervision in a hospital or clinical setting

• Not recommended during pregnancy or breastfeeding unless clearly indicated

Storage

Store below 25°C in a dry place, protected from light. Keep out of reach of children. Use the reconstituted solution immediately according to clinical protocols.

Perinem Injection 500 mg/vial provides potent, broad-spectrum antibacterial therapy for severe and complicated infections, ensuring rapid and effective management under professional medical supervision.