Pendoril Plus Tablet 4 mg + 1.25 mg is a combination antihypertensive therapy that combines Perindopril (4 mg) and Indapamide (1.25 mg) to provide effective management of high blood pressure (hypertension). This combination harnesses the complementary actions of an ACE inhibitor and a thiazide-like diuretic to achieve optimal blood pressure control while protecting vital organs such as the heart and kidneys.

Perindopril, an ACE inhibitor, works by relaxing blood vessels, reducing the production of angiotensin II, and lowering blood pressure. It also helps decrease the workload on the heart and provides protective effects for the kidneys and cardiovascular system. Indapamide, a thiazide-like diuretic, promotes the excretion of sodium and water, reducing blood volume and further lowering blood pressure. Together, these agents provide synergistic antihypertensive effects, making Pendoril Plus 4 mg + 1.25 mg suitable for patients requiring stronger or combination therapy.

This formulation is especially beneficial for patients with moderate to severe hypertension, or for those who did not achieve adequate blood pressure control with monotherapy. The tablet’s oral form ensures convenient once-daily dosing for adherence and long-term management.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Features

• Contains Perindopril 4 mg + Indapamide 1.25 mg per tablet

• Combination therapy for enhanced blood pressure control

• ACE inhibitor relaxes blood vessels and lowers blood pressure

• Diuretic reduces fluid retention and blood volume

• Protects the heart, kidneys, and vascular system

• Oral tablet for convenient once-daily use

• Suitable for moderate to severe hypertension or step-up therapy

Indications

Pendoril Plus Tablet 4 mg + 1.25 mg is indicated for:

• Hypertension: Effective for patients requiring combination therapy to reach target blood pressure

• Cardiovascular risk reduction: Lowers the risk of heart attack, stroke, and other cardiovascular events

• Edema management: Helps reduce fluid retention associated with hypertension

• Patients with insufficient response to monotherapy: Provides a step-up approach for better control

Mechanism of Action

The combination works through complementary mechanisms:

• Perindopril (ACE inhibitor): Inhibits the conversion of angiotensin I to angiotensin II, leading to vasodilation, decreased aldosterone secretion, and reduced blood pressure. It also protects the heart and kidneys from long-term hypertension-related damage.

• Indapamide (thiazide-like diuretic): Increases the excretion of sodium and water, reducing blood volume and contributing to lower blood pressure. It also mildly dilates blood vessels, enhancing antihypertensive effects.

This dual action ensures efficient blood pressure reduction and cardiovascular protection.

Dosage and Administration

• Recommended dose: 1 tablet orally once daily, preferably at the same time each day

• Can be taken with or without food

• Dose adjustments may be required in patients with kidney or liver impairment

• Regular monitoring of blood pressure, kidney function, and electrolytes is recommended

• Suitable for patients needing stronger therapy after monotherapy

Possible Side Effects

Common side effects:

• Dizziness or lightheadedness, especially after the first dose

• Fatigue or weakness

• Headache

• Mild cough

• Increased urination due to diuretic effect

Rare but serious side effects:

• Severe hypotension

• Angioedema (swelling of face, lips, or throat)

• Electrolyte imbalances (low potassium or sodium)

• Kidney dysfunction

Patients should seek immediate medical attention if they experience severe swelling, difficulty breathing, fainting, or persistent electrolyte-related symptoms.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Use under medical supervision, particularly in patients with kidney or liver disease

• Regular monitoring of blood pressure, kidney function, and electrolytes is essential

• Avoid use during pregnancy or breastfeeding

• Inform your healthcare provider of all medications to prevent interactions

• Caution in patients taking other diuretics, ACE inhibitors, or antihypertensive agents

Storage Instructions

• Store in a cool, dry place below 25°C

• Protect from light and moisture

• Keep tablets in the original container, tightly closed

• Keep out of reach of children.