Othera Tablet 40 mg contains Esomeprazole in a Multiple Unit Pellet System (MUPS) formulation, a potent proton pump inhibitor (PPI) that suppresses gastric acid secretion. By selectively inhibiting the H+/K+ ATPase enzyme in stomach parietal cells, Esomeprazole effectively reduces both basal and stimulated gastric acid production. Othera 40 mg is designed for the management of more severe acid-related gastrointestinal conditions, including gastroesophageal reflux disease (GERD), erosive esophagitis, peptic ulcers, and Zollinger-Ellison syndrome. The MUPS technology allows the tablet to be swallowed whole or dispersed in water for patients who have difficulty swallowing.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Othera Tablet 40 mg is indicated for:

• Treatment of erosive esophagitis due to GERD
• Symptomatic management of severe GERD
• Prevention and treatment of gastric and duodenal ulcers
• Part of Helicobacter pylori eradication therapy in combination with antibiotics
• Management of Zollinger-Ellison syndrome and other hypersecretory conditions
• Prevention of NSAID-induced gastric ulcers in high-risk patients

Mechanism of Action

Esomeprazole, the active ingredient, acts by:

• Irreversibly inhibiting the H+/K+ ATPase enzyme (proton pump) in gastric parietal cells
• Suppressing gastric acid secretion effectively and for a prolonged period
• Allowing healing of acid-related injuries in the esophagus, stomach, and duodenum
• MUPS technology ensures uniform absorption and efficacy even if the tablet is dispersed in water

This targeted action reduces symptoms such as heartburn, acid regurgitation, and stomach discomfort.

Dosage and Administration

• Adults: Typically 40 mg once daily, 30–60 minutes before a meal, or as prescribed by a physician
• For patients with swallowing difficulties, the tablet can be dispersed in water and ingested immediately
• Duration of therapy depends on the condition; erosive esophagitis may require 4–8 weeks, while hypersecretory conditions may need long-term management
• Do not crush or chew the tablet if swallowing whole

Benefits

• Potent acid suppression for effective relief of heartburn and reflux symptoms
• Promotes healing of erosive esophagitis and peptic ulcers
• Supports H. pylori eradication therapy when combined with antibiotics
• MUPS formulation allows flexible administration for adults and elderly patients
• Improves gastrointestinal comfort and overall quality of life

Possible Side Effects

Othera Tablet 40 mg is generally well-tolerated. Common side effects may include:

• Headache
• Nausea, vomiting, or diarrhea
• Abdominal pain or flatulence
• Rare side effects: dizziness, rash, hypersensitivity reactions
• Long-term use may rarely lead to vitamin B12 deficiency or low magnesium levels; periodic monitoring may be required

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Avoid in patients with known hypersensitivity to Esomeprazole or other PPIs
• Use with caution in patients with severe liver impairment
• Inform your doctor of all concurrent medications to avoid drug interactions (e.g., clopidogrel, ketoconazole, warfarin)
• Use under medical supervision during pregnancy or breastfeeding
• Report persistent diarrhea or unusual gastrointestinal symptoms

Storage

• Store below 25°C in a cool, dry place
• Keep the tablet in its original container
• Protect from moisture and light
• Keep out of reach of children.