Othera Injection 40 mg contains Esomeprazole in a MUPS (Multiple Unit Pellet System) preparation, formulated for intravenous administration. Esomeprazole is a proton pump inhibitor (PPI) that effectively suppresses gastric acid secretion by selectively inhibiting the H+/K+ ATPase enzyme in stomach parietal cells. Othera Injection provides rapid and reliable acid suppression, making it ideal for patients who cannot take oral medication or require immediate therapy in cases of severe acid-related disorders, including gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Othera Injection 40 mg is indicated for:

• Short-term treatment of erosive esophagitis due to GERD
• Symptomatic management of severe GERD when oral therapy is not feasible
• Prevention and treatment of gastric and duodenal ulcers
• Part of Helicobacter pylori eradication therapy in combination with antibiotics
• Management of Zollinger-Ellison syndrome and other hypersecretory conditions
• Patients requiring intravenous acid suppression in critical care or perioperative settings

Mechanism of Action

Esomeprazole, the active ingredient, works by:

• Irreversibly inhibiting the H+/K+ ATPase (proton pump) in gastric parietal cells
• Reducing both basal and stimulated gastric acid secretion
• Providing rapid and prolonged acid suppression
• Allowing healing of erosions in the esophagus, stomach, and duodenum
• Ensuring consistent bioavailability through intravenous administration

This targeted action effectively alleviates symptoms such as heartburn, acid regurgitation, and gastric discomfort.

Dosage and Administration

• Adults: 40 mg administered as a slow intravenous injection or diluted in compatible IV fluids as prescribed by a physician
• Pediatric dose: Determined based on age and weight under medical supervision
• Injection should be administered under the supervision of a healthcare professional
• Duration of therapy depends on the condition; some patients may require continued oral therapy after IV treatment
• Follow the prescribed dosing schedule for optimal efficacy

Benefits

• Rapid and effective acid suppression for immediate relief of severe GERD and ulcers
• Suitable for patients unable to take oral medications
• Supports healing of erosive esophagitis and peptic ulcers
• Useful in critical care settings and perioperative management
• Well-tolerated with a favorable safety profile

Possible Side Effects

Othera Injection is generally well-tolerated. Possible side effects include:

• Headache
• Nausea or mild diarrhea
• Local reactions at the injection site
• Rare side effects: dizziness, rash, or hypersensitivity reactions
• Very rare: changes in liver function tests or magnesium levels with prolonged therapy

Consult a healthcare provider if severe or persistent side effects occur.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Not recommended for patients with hypersensitivity to Esomeprazole or other PPIs
• Use with caution in patients with severe liver impairment
• Monitor for drug interactions with medications such as clopidogrel, ketoconazole, or warfarin
• Use under medical supervision during pregnancy or breastfeeding
• Report persistent gastrointestinal symptoms or unusual reactions

Storage

• Store below 25°C in a cool, dry place
• Protect from light and moisture
• Keep the vial tightly closed
• Keep out of reach of children.