Novaclav Injection (1 gm+200 mg)/20 ml is a combination antibiotic containing Amoxicillin and Clavulanic Acid. It is used for the treatment of moderate to severe bacterial infections when oral therapy is not suitable or when rapid clinical response is required. The inclusion of Clavulanic Acid helps overcome bacterial resistance by inhibiting beta-lactamase enzymes, making Amoxicillin more effective against a wide range of pathogens.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Amoxicillin Sodium equivalent to Amoxicillin 1 gm
• Clavulanic Acid Potassium equivalent to Clavulanic Acid 200 mg
• Diluent: Sterile Water for Injection (20 ml vial/ampoule)

Mechanism of Action

Amoxicillin works by inhibiting bacterial cell wall synthesis, leading to bacterial death. However, some bacteria produce beta-lactamase enzymes that inactivate Amoxicillin. Clavulanic Acid acts as a beta-lactamase inhibitor, protecting Amoxicillin from enzymatic degradation and restoring its antibacterial activity. Together, they provide broad-spectrum bactericidal action against susceptible organisms.

Indications

Novaclav Injection is indicated for the treatment of:

• Severe respiratory tract infections (pneumonia, bronchitis)
• Urinary tract infections (complicated UTIs, pyelonephritis)
• Intra-abdominal infections
• Skin and soft tissue infections
• Bone and joint infections
• Post-surgical and hospital-acquired infections
• Severe dental infections

Dosage and Administration

• Administered only by a qualified healthcare professional.
• Given via intravenous (IV) injection or infusion after proper dilution.
• Dosage depends on severity of infection, patient age, weight, and renal function.
• The injection should be given slowly to minimize adverse reactions.
• Treatment duration is determined by clinical response and physician guidance.

Benefits

• Broad-spectrum antibacterial coverage
• Effective against beta-lactamase producing resistant bacteria
• Rapid onset of action via intravenous route
• Useful in severe and hospitalized infection cases
• Helps reduce complications of untreated bacterial infections

Side Effects

Common side effects may include:

• Nausea and vomiting
• Diarrhea
• Injection site pain or irritation
• Rash
• Headache

Serious but rare side effects:

• Severe allergic reactions (anaphylaxis)
• Liver dysfunction or hepatitis
• Blood disorders (e.g., thrombocytopenia, leukopenia)
• Severe antibiotic-associated colitis (C. difficile infection)

Immediate medical attention is required if severe reactions occur.

Precautions and Warnings

• Use cautiously in patients with penicillin allergy.
• Monitor renal function in long-term or high-dose therapy.
• Adjust dose in patients with kidney impairment.
• Prolonged use may lead to secondary fungal or bacterial infections.
• Pregnancy and breastfeeding use should be guided by a physician.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Novaclav Injection may interact with:

• Allopurinol (increased risk of rash)
• Anticoagulants (e.g., warfarin)
• Methotrexate (increased toxicity risk)
• Probenecid (increases amoxicillin levels)
• Oral contraceptives (possible reduced effectiveness)

Always inform the healthcare provider about all ongoing medications.

Storage

• Store below 25°C in a cool, dry place
• Protect from light and moisture
• Reconstituted solution should be used immediately as directed
• Keep out of reach of children.