Niloren Capsule 150 mg contains Nilotinib, a tyrosine kinase inhibitor (TKI) designed for the treatment of Philadelphia chromosome-positive chronic myeloid leukemia (CML). Nilotinib selectively inhibits the BCR-ABL protein, which drives the uncontrolled growth of leukemia cells. This capsule is typically prescribed for patients with newly diagnosed CML in the chronic phase or those requiring a lower starting dose due to tolerance, age, or comorbid conditions. Niloren 150 mg offers targeted therapy, improving disease control while minimizing systemic toxicity.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Niloren Capsule 150 mg is indicated for:

• Adult patients with Philadelphia chromosome-positive chronic myeloid leukemia (CML) in the chronic phase

• Newly diagnosed CML patients who require a lower initial dose

• Patients with specific tolerability or safety considerations

• Management of disease progression prevention in CML

Mechanism of Action

Nilotinib works by:

• Blocking BCR-ABL tyrosine kinase, halting abnormal leukemia cell proliferation

• Inhibiting signaling pathways that promote uncontrolled division of malignant cells

• Reducing leukemia cell counts in blood and bone marrow

• Providing targeted therapy with higher specificity than traditional chemotherapy

Dosage and Administration

• Recommended starting dose: 150 mg orally twice daily or as prescribed by a hematologist

• Take on an empty stomach, at least 1 hour before or 2 hours after meals

• Swallow capsules whole; do not crush, chew, or open

• Regular blood counts, liver function, and ECG monitoring are essential during therapy

Benefits

• Targeted therapy for CML with high specificity

• Helps achieve hematologic and cytogenetic remission

• Reduces risk of disease progression

• Oral administration allows convenient outpatient treatment

• Well-tolerated with manageable side effects under supervision

Precautions

• Inform your doctor if you have:

  • Heart conditions, including prolonged QT interval or arrhythmias

  • Liver or kidney impairment

  • History of pancreatitis

• Avoid grapefruit and grapefruit juice, which may interfere with metabolism

• Adhere strictly to the prescribed dosage and monitoring schedule

Side Effects

Common side effects may include:

• Fatigue

• Nausea or vomiting

• Headache

• Rash or mild skin reactions

Serious side effects can include:

• QT interval prolongation or cardiac arrhythmias

• Elevated liver enzymes

• Pancreatitis

• Myelosuppression (low blood counts)

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store at room temperature (20–25°C)

• Keep in a dry place away from light

• Keep out of reach of children

Conclusion

Niloren Capsule 150 mg provides effective, targeted therapy for Philadelphia chromosome-positive CML, particularly for patients requiring a lower starting dose. By inhibiting the BCR-ABL tyrosine kinase, it controls leukemia progression, supports remission, and ensures safer, manageable treatment under medical supervision.