Nebicard Plus Tablet 5 mg + 12.5 mg is a combination medication containing Nebivolol, a selective beta-1 adrenergic receptor blocker, and Hydrochlorothiazide, a thiazide diuretic. This fixed-dose formulation is designed to provide effective management of hypertension by targeting two complementary mechanisms: reducing cardiac workload and promoting fluid excretion.

Nebivolol lowers heart rate and systemic vascular resistance, while Hydrochlorothiazide enhances sodium and water excretion through the kidneys, leading to a decrease in blood volume. The combination offers superior blood pressure control compared to either component alone and is particularly useful for patients requiring dual therapy for hypertension.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Nebivolol 5 mg

• Hydrochlorothiazide 12.5 mg

Mechanism of Action

Nebivolol selectively blocks beta-1 adrenergic receptors in the heart, reducing the effects of catecholamines such as adrenaline. This decreases heart rate, myocardial contractility, and cardiac output, effectively lowering blood pressure. Additionally, Nebivolol promotes the release of nitric oxide from the endothelium, causing vasodilation and improved blood flow.

Hydrochlorothiazide is a thiazide diuretic that inhibits sodium reabsorption in the distal convoluted tubules of the kidneys. This action increases urinary excretion of sodium and water, reducing blood volume and peripheral resistance, which contributes to lowering blood pressure.

Indications

Nebicard Plus Tablet 5 mg + 12.5 mg is indicated for:

• Essential hypertension (high blood pressure)

• Patients requiring dual therapy for better blood pressure control

• Cardiovascular risk reduction in hypertensive patients

This combination is ideal for patients whose blood pressure is not adequately controlled by monotherapy.

Dosage and Administration

The dosage should be individualized by a registered physician based on the patient’s blood pressure, heart rate, and kidney function. Nebicard Plus is usually taken once daily, at the same time each day, with or without food.

The tablet should be swallowed whole with water. Abrupt discontinuation should be avoided, as sudden cessation may lead to rebound hypertension or exacerbation of cardiovascular conditions.

Benefits

• Effective and sustained blood pressure reduction

• Dual mechanism targets both cardiac output and fluid retention

• Reduces the risk of cardiovascular complications associated with hypertension

• Improves endothelial function through nitric oxide-mediated vasodilation

• Convenient once-daily dosing enhances adherence

Possible Side Effects

Common side effects may include:

• Dizziness or lightheadedness

• Fatigue

• Headache

• Mild gastrointestinal discomfort

• Increased urination

Less common but serious side effects may include severe hypotension, electrolyte imbalance (low potassium or sodium), kidney dysfunction, or bradycardia. Patients should seek immediate medical attention if experiencing severe dizziness, fainting, chest pain, or abnormal heart rhythm.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use cautiously in patients with kidney or liver impairment, electrolyte imbalances, or heart conditions.

• Regular monitoring of blood pressure, kidney function, and electrolytes is recommended during therapy.

• Avoid abrupt discontinuation to prevent rebound hypertension.

• Inform your physician of all other medications being taken, especially antihypertensives or diuretics.

• Pregnancy and breastfeeding use should be under physician guidance.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Nebicard Plus Tablet 5 mg + 12.5 mg offers an effective, convenient, and well-tolerated option for patients requiring combination therapy to control hypertension and reduce cardiovascular risk under proper medical supervision.