Naspro Plus Tablet 500 mg+20 mg is a combination medication formulated with Naproxen Sodium, a potent non-steroidal anti-inflammatory drug (NSAID), and Esomeprazole Magnesium, a proton pump inhibitor (PPI). This combination is designed to deliver strong and long-lasting pain relief while minimizing the risk of gastrointestinal complications such as ulcers and acid-related irritation. It is particularly suitable for patients requiring higher doses of NSAIDs for chronic inflammatory conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Naproxen Sodium 500 mg
• Esomeprazole Magnesium 20 mg

Mechanism of Action

Naproxen Sodium works by blocking cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the production of prostaglandins that cause pain, inflammation, and fever.

Esomeprazole Magnesium acts by inhibiting the gastric proton pump (H+/K+ ATPase), leading to a significant reduction in stomach acid secretion. This helps protect the stomach lining and reduces the risk of NSAID-induced gastric ulcers and irritation.

The combination ensures effective symptom control along with improved gastrointestinal safety.

Indications

Naspro Plus Tablet 500 mg+20 mg is indicated for:

• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Chronic joint and muscle pain
• Back pain and inflammatory conditions
• Patients requiring long-term NSAID therapy with gastric protection

Dosage and Administration

• Use as directed by a registered healthcare professional.
• Typically taken before meals to enhance the effect of esomeprazole.
• Swallow the tablet whole with a full glass of water.
• Do not crush, break, or chew the tablet.
• Follow the prescribed dose and duration strictly.

Benefits

• Provides powerful and sustained pain relief
• Effectively reduces inflammation and swelling
• Protects against stomach irritation and ulcer formation
• Suitable for long-term therapy under medical supervision
• Improves patient convenience with a combination formula

Side Effects

Common side effects may include:

• Nausea
• Abdominal pain
• Indigestion
• Headache
• Diarrhea or constipation

Serious but rare side effects:

• Gastrointestinal bleeding or ulcer
• Severe allergic reactions
• Kidney or liver dysfunction
• Increased risk of cardiovascular events with prolonged use
• Vitamin B12 deficiency with long-term therapy

Immediate medical attention is necessary if any serious adverse effects occur.

Precautions and Warnings

• Use cautiously in patients with a history of peptic ulcers or gastrointestinal bleeding.
• Patients with cardiovascular disease, hypertension, or renal impairment should consult a physician before use.
• Avoid alcohol consumption as it increases the risk of stomach irritation.
• Long-term use should be monitored by a healthcare provider.
• Not recommended during the last trimester of pregnancy unless advised by a doctor.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Naspro Plus may interact with:

• Other NSAIDs or aspirin
• Anticoagulants (e.g., warfarin)
• Antiplatelet agents such as clopidogrel
• Corticosteroids
• Diuretics and antihypertensive medications
• Certain antifungal and antiviral drugs
• Medicines affected by gastric pH levels

Always inform your healthcare provider about all medications and supplements you are taking.

Storage

• Store below 30°C in a dry and cool place
• Protect from direct sunlight and moisture
• Keep out of reach of children.