Evo Injection 500 mg/100 ml contains Levofloxacin Hemihydrate, a broad-spectrum fluoroquinolone antibiotic used for the treatment of a wide range of serious bacterial infections. This intravenous formulation is particularly indicated for hospitalized patients or those who are unable to take oral medication. Evo Injection delivers rapid and effective antibacterial action, making it a reliable option in moderate to severe infections.

Levofloxacin is known for its excellent tissue penetration and activity against both gram-positive and gram-negative bacteria, as well as atypical pathogens. Evo Injection is commonly used in respiratory, urinary tract, skin, and systemic infections where prompt intravenous therapy is required.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Levofloxacin Hemihydrate

• Strength: 500 mg per 100 ml

• Dosage Form: Intravenous infusion

Therapeutic Class

Fluoroquinolone Antibiotic

Mechanism of Action

Levofloxacin exerts its bactericidal effect by inhibiting two essential bacterial enzymes: DNA gyrase and topoisomerase IV. These enzymes are required for DNA replication, transcription, repair, and recombination.

By blocking these enzymes, levofloxacin disrupts bacterial DNA synthesis, leading to rapid bacterial cell death. This mechanism provides strong activity against a wide range of susceptible organisms and helps ensure effective infection control.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Evo Injection 500 mg/100 ml is indicated for the treatment of infections caused by levofloxacin-sensitive bacteria, including:

• Community-acquired pneumonia

• Hospital-acquired pneumonia

• Acute bacterial exacerbation of chronic bronchitis

• Complicated and uncomplicated urinary tract infections

• Acute pyelonephritis

• Skin and soft tissue infections

• Prostatitis

• Intra-abdominal infections (in combination with appropriate agents)

• Septicemia and other systemic infections

Dosage and Administration

Evo Injection is administered by slow intravenous infusion under the supervision of a healthcare professional.

• The usual adult dose is 500 mg once daily

• Infusion should be given over at least 60 minutes

• Dosage adjustment may be necessary in patients with renal impairment

The duration of therapy depends on the type and severity of infection and the patient’s clinical response. Patients may be switched to oral levofloxacin when clinically appropriate.

Precautions and Warnings

• Use with caution in patients with renal dysfunction

• Not recommended for children and adolescents due to risk of joint and cartilage disorders

• Risk of tendonitis and tendon rupture, especially in elderly patients and those on corticosteroids

• May cause QT interval prolongation; caution in patients with cardiac conditions

• Avoid unnecessary exposure to sunlight due to risk of photosensitivity

Possible Side Effects

Evo Injection is generally well tolerated, but some patients may experience:

• Nausea, vomiting, or diarrhea

• Headache or dizziness

• Injection site reactions

• Elevated liver enzymes

• Rarely, tendon disorders or central nervous system effects

Any severe or persistent adverse reactions should be reported to a healthcare provider immediately.

Storage

Store below 25°C. Protect from light. Do not freeze. Keep out of reach of children.

Benefits of Evo Injection 500 mg/100 ml

• Broad-spectrum antibacterial coverage

• Rapid intravenous action for severe infections

• Once-daily dosing convenience

• Proven efficacy and safety profile.