Nalepsin IV Infusion 4 gm/100 ml contains Magnesium Sulphate Heptahydrate, a specific mineral preparation widely used in critical care and emergency settings. It plays an essential role in the prevention and management of convulsions, correction of magnesium deficiency, and stabilization of neuromuscular and cardiovascular functions. Due to its rapid onset of action when administered intravenously, Nalepsin is particularly valuable in acute and life-threatening conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Indications

Nalepsin IV Infusion is indicated for the management and prevention of the following conditions:

• Prevention and control of convulsions in preeclampsia and eclampsia

• Management of convulsions associated with tetanus and acute uraemia

• Treatment of cardiac arrhythmias, including those occurring in acute myocardial infarction

• Arrest of premature labour

• As an adjuvant in neurosurgical procedures to reduce cerebrospinal fluid (CSF) pressure

• Replacement therapy in patients with hypomagnesaemia

• Control of hypertension, encephalopathy, and convulsions related to acute nephritis in children

Pharmacology

Magnesium is the second most abundant intracellular cation and is vital for numerous biochemical processes. It acts as a cofactor for many enzymatic reactions and plays a key role in neuromuscular transmission and muscle excitability. Low extracellular magnesium levels increase acetylcholine release, leading to heightened neuromuscular excitability and possible tetany.

Parenterally administered Magnesium Sulphate exhibits potent anticonvulsant properties by depressing central nervous system activity and reducing neuromuscular transmission. Approximately 25–30% of magnesium is protein bound after administration. It is primarily excreted through the kidneys, with more than 90% reabsorbed in the renal tubules. Small amounts are excreted in feces, saliva, and breast milk, and magnesium readily crosses the placenta.

Dosage and Administration

• Maximum daily dose: Up to 40 gm, administered at a rate not exceeding 3 ml per minute

• Preeclampsia/Eclampsia: Loading dose of 4 gm (100 ml) over up to 20 minutes, followed by 2 gm (50 ml) per hour as maintenance

• Myocardial infarction: 8 mmol (50 ml) over 20 minutes, then 65 mmol (400 ml) over 24 hours

• Magnesium deficiency: 0.5–1 mmol/kg/day initially, followed by maintenance dosing as required
  Dosage should be individualized based on clinical condition and patient response.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Concomitant use with barbiturates, narcotics, hypnotics, or other CNS depressants may enhance central nervous system depression, requiring careful dose adjustment.

Contraindications

Nalepsin is contraindicated in patients with heart block or significant myocardial damage.

Adverse Effects

Excessive dosing may result in hypermagnesaemia, presenting with nausea, vomiting, flushing, hypotension, drowsiness, loss of tendon reflexes, respiratory depression, and, in severe cases, cardiac arrest.

Precautions and Warnings

Caution is advised in patients with renal or hepatic impairment. Continuous monitoring is essential during infusion. Discontinue use if the solution is cloudy, contains particles, or if the container is damaged.

Storage Conditions

Store at controlled room temperature and protect from light. This IV infusion is intended for single use only.